QacA-mediated Multidrug Resistance And Export In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$497,250.00
Summary
Strains of the pathogenic bacterium Staphylococcus aureus (Golden Staph) which are resistant to almost all available anti-staphylococcal agents are responsible for serious infections among hospitalised patients; in some hospitals such outbreaks reach epidemic proportions. In these bacteria, resistance has emerged to all classes of antimicrobial agents, including antibiotics and antiseptics-disinfectants commonly used in the hospital environment, largely due to the acquisition of resistance deter ....Strains of the pathogenic bacterium Staphylococcus aureus (Golden Staph) which are resistant to almost all available anti-staphylococcal agents are responsible for serious infections among hospitalised patients; in some hospitals such outbreaks reach epidemic proportions. In these bacteria, resistance has emerged to all classes of antimicrobial agents, including antibiotics and antiseptics-disinfectants commonly used in the hospital environment, largely due to the acquisition of resistance determinants. These determinants encode for proteins which provide the bacterial cell with a range of different biochemical mechanisms to evade antibiotic chemotherapy. Specifically, this project seeks to increase our understanding of proteins which confer resistance by pumping a variety of structurally-dissimilar antimicrobials out of the bacterial cell. Proteins which recognise such a broad spectrum of compounds are called multidrug resistance proteins and present a disturbing clinical threat since the acquisition of one such system by a cell may simultaneously decrease its susceptibility to a number of antimicrobials. Similar multidrug pumps are widespread in nature and are credited for resistance to antibiotics and other chemotherapeutic drugs in many pathogenic organisms, such as the bacteria responsible for tuberculosis, and in human cancer cells. In this project, we aim to characterise the QacA multidrug resistance protein which is involved in pumping many different antimicrobial compounds from staphylococcal cells. We will identify the regions of the QacA multidrug resistance protein which bind the compounds and examine how the protein expels them to give resistance. These studies are a prerequisite for the design of more effective antibacterial compounds able to bypass or block these drug resistance pumps, and will also provide fundamental knowledge applicable to the problem of multidrug resistance in other infectious diseases and cancer.Read moreRead less
QacA-mediated Multidrug Resistance And Export In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$437,545.00
Summary
Strains of the pathogenic bacterium Staphylococcus aureus (Golden Staph) which are resistant to almost all available anti-staphylococcal agents are responsible for serious infections among hospitalised patients; in some hospitals such outbreaks reach epidemic proportions. In these bacteria, resistance has emerged to all classes of antimicrobial agents, including antibiotics and antiseptics-disinfectants commonly used in the hospital environment, largely due to the acquisition of resistance deter ....Strains of the pathogenic bacterium Staphylococcus aureus (Golden Staph) which are resistant to almost all available anti-staphylococcal agents are responsible for serious infections among hospitalised patients; in some hospitals such outbreaks reach epidemic proportions. In these bacteria, resistance has emerged to all classes of antimicrobial agents, including antibiotics and antiseptics-disinfectants commonly used in the hospital environment, largely due to the acquisition of resistance determinants. These determinants encode for proteins which provide the bacterial cell with a range of different biochemical mechanisms to evade antibiotic chemotherapy. Specifically, this project seeks to increase our understanding of proteins which confer resistance by pumping a variety of structurally-dissimilar antimicrobials out of the bacterial cell. Proteins which recognise such a broad spectrum of compounds are called multidrug resistance proteins and present a disturbing clinical threat since the acquisition of one such system by a cell may simultaneously decrease its susceptibility to a number of antimicrobials. Similar multidrug pumps are widespread in nature and are credited for resistance to antibiotics and other chemotherapeutic drugs in many pathogenic organisms, such as the bacteria responsible for tuberculosis, and in human cancer cells. In this project, we aim to characterise the QacA multidrug resistance protein which is involved in pumping many different antimicrobial compounds from staphylococcal cells. We will identify the regions of the QacA multidrug resistance protein which bind the compounds and examine how the protein expels them to give resistance. These studies are a prerequisite for the design of more effective antibacterial compounds able to bypass these drug resistance pumps, and will also provide fundamental knowledge applicable to the problem of multidrug resistance in other infectious diseases and cancer.Read moreRead less
Seafood Trade Advisory Group - Transitioning To A New Communications, Governance And Operating Model
Funder
Fisheries Research and Development Corporation
Funding Amount
$444,000.00
Summary
The STAG has been operational since 2013 providing services to Australian abalone and rock lobster exporters to engage with government and to support in market access negotiations with unified and well researched considered input. The STAG has a track record of success based on a collaborative priority setting process and a clear focus on resolving the highest priority issues. While primarily focused on the issues faced by abalone and rock lobster exporters many of the STAG activities have be ....The STAG has been operational since 2013 providing services to Australian abalone and rock lobster exporters to engage with government and to support in market access negotiations with unified and well researched considered input. The STAG has a track record of success based on a collaborative priority setting process and a clear focus on resolving the highest priority issues. While primarily focused on the issues faced by abalone and rock lobster exporters many of the STAG activities have benefited the broader seafood exporter community eg the International Freight Assistance Mechanism, tracking and communicating impacts of the COVID pandemic on markets, facilitating an agreed priority listing for adding new species to the approved import list for China and establishing a market intelligence service has been established and weekly newsletters keep Australian seafood exporters up to date on market trends and consumer insights as well as technical market access issues.
Seafood Industry Australia has recently developed a Seafood Industry Export Plan. As part of that plan SIA is building capability and has received Australian Government funding through the ATMAC funding to deliver trade facilitation services.
There is an opportunity for the STAG to move to a new expanded business model under the auspices of SIA capitalising on the resources and capacities of both organisations. The new model will include communications, governance, operations and funding. What that looks like and how that transition should occur will be addressed through application.
While the transition plan is being developed, agreed and implemented it is important that the STAG to continue operations, providing services as agreed by the Partnership Group. The international trade environment is still extremely volatile, as it has been for the past two years. The STAG provides a valuable early warning and quick response mechanism for dealing with disruptions, a market intelligence service and international seafood trade expertise to support the Abalone and Rock Lobster sectors as they face the challenging task of regaining and maintaining China market access while pursuing market diversification strategies.
There is a need to build additional seafood specific international trade knowledge and capacity so the STAG and SIA will work together to identify opportunities to facilitate this. Objectives: 1. To develop and implement agreed arrangements to transition the STAG to a new business model (communications, governance, operations and funding) within the SIA 2. To deliver agreed trade and market access services according to the agreed Seafood Trade Agenda and Action Plan for Abalone and Rock Lobster Read moreRead less