Meta-research: Using Research To Increase The Value Of Health And Medical Research
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Improving the return on investment in health and medical research will produce more and faster discoveries that enhance the lives of all Australians. Many problems in the research process are well known and have been pervasive for decades. I will use the research process to improve the research process. I will improve Australia's health and medical research workforce and the quality of the research they produce, creating benefits in multiple fields that last long into the future.
Development Of Statistical Methodologies And Application To Clinical Cancer Studies
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Integrating different layers of information coming from the recent ‘-omics’ technologies can help improving the treatment and the prevention of complex diseases. In particular, the identification of molecular markers of different types can be used for better diagnostics and prognosis in cancer and immune diseases. This project will develop innovative statistical solutions to handle and make sense of the vast amount of biological data that are routinely generated in the laboratories.
Min/Max Autocorrelation Factors in Time Series Studies of the Adverse Health Effects of Ozone. The annual health costs associated with exposure to air pollution in Australia have been estimated at between $3 and 5.3 billion. Given these costs, it is vital to conduct research that ensures public health officials and policy makers stay fully informed of Australia’s air pollution problem. The project proposes to address this need by developing methodology to detect trends in air pollution concentra ....Min/Max Autocorrelation Factors in Time Series Studies of the Adverse Health Effects of Ozone. The annual health costs associated with exposure to air pollution in Australia have been estimated at between $3 and 5.3 billion. Given these costs, it is vital to conduct research that ensures public health officials and policy makers stay fully informed of Australia’s air pollution problem. The project proposes to address this need by developing methodology to detect trends in air pollution concentrations and reduce measurement error in recorded air pollution concentrations. This will enable relevant authorities to produce more accurate estimates of air pollution health costs and implement more appropriate pollution regulations and health warnings.Read moreRead less
Goodness-of-fit Testing Of Log-link Models For Categorical Outcome Data
Funder
National Health and Medical Research Council
Funding Amount
$260,863.00
Summary
Information about the health consequences of exposure to causal factors is obtained from mathematical models of observed data. Incorrect inferences are possible if the model does not adequately represent the data. Relative risk models are recommended for observations over time on a cohort of subjects, but it is not known how best to assess the adequacy of such models. This project will assess the performance of summary measures of goodness-of-fit when applied to relative risk models.
Bayesian statistical models for understanding outcomes and improving decision-making for women screened for breast cancer. This project has two key benefits: (i) the development of frontier statistical methods for spatio-temporal analysis and data synthesis, which are imperative in a wide range of disciplines; and (ii) the application of these methods for improved understanding of breast cancer outcomes for women screened in Queensland. The project results will lead to direct health and financi ....Bayesian statistical models for understanding outcomes and improving decision-making for women screened for breast cancer. This project has two key benefits: (i) the development of frontier statistical methods for spatio-temporal analysis and data synthesis, which are imperative in a wide range of disciplines; and (ii) the application of these methods for improved understanding of breast cancer outcomes for women screened in Queensland. The project results will lead to direct health and financial benefits through targeted policies for increasing screening uptake and reducing cancer morbidity and mortality and therefore health spending in this area. Importantly, the project represents an excellent training opportunity to develop a PhD candidate into an experienced interdisciplinary researcher.Read moreRead less
Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends ....Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends to create by linking individual records across censuses. These benefits will be maximised by controlling the impact of linkage error when analysing these datasets. This proposal will develop the statistical theory and related methodology to solve this problem in a statistically efficient manner.Read moreRead less
Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and pro ....Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and provide more informed advice to the public on the necessity of avoiding exposure to air pollutants. These two outcomes are particularly important given Australia's ageing population and the fact that the elderly are among those most susceptible to harm from air pollution exposure.Read moreRead less
New methods for analysing marketing Databases in the age of digital media. This is a time of enormous and rapid change in many areas of Australian business due to the introduction and widespread dissemination of digital media. It has resulted in the accumulation of large integrated databases of customer information and their transactions. Firms in all countries, particularly those challenged by distance and size, like Australia, are now seeking to find ways to make better use of their voluminous ....New methods for analysing marketing Databases in the age of digital media. This is a time of enormous and rapid change in many areas of Australian business due to the introduction and widespread dissemination of digital media. It has resulted in the accumulation of large integrated databases of customer information and their transactions. Firms in all countries, particularly those challenged by distance and size, like Australia, are now seeking to find ways to make better use of their voluminous information so as to make efficiency gains in their business processes, strategic decision-making and customer relationship management. Our project aims to contribute to the ARC priority research goal of smart information use by developing new methodologies for the analysis of these large integrated databases.Read moreRead less
Design And Analysis Of Interrupted Time Series Studies In Health Care Research: Resolution Of Methodological Issues
Funder
National Health and Medical Research Council
Funding Amount
$307,125.00
Summary
An interrupted time series (ITS) study involves a population observed on multiple occasions before and after the implementation of an intervention program. However, methods for statistical analysis and designing such studies have not been well developed and many statistical analyses of such studies are flawed. This proposal will investigate appropriate methods for design and analysis, and develop guidelines and software for its implementation by health researchers.
WaterLog - A mathematical model to implement recommendations of The Wentworth Group. In 2003, The Wentworth Group of Concerned Scientists released their 'Blueprint for a national water plan' with the primary objective to 'protect river health and the rights of all Australians to clean usable water'. Currently, there are significant water restrictions in all the Australian mainland capital cities. In January 2007, the Prime Minister of Australia, announced a bold plan to rescue the Murray-Darling ....WaterLog - A mathematical model to implement recommendations of The Wentworth Group. In 2003, The Wentworth Group of Concerned Scientists released their 'Blueprint for a national water plan' with the primary objective to 'protect river health and the rights of all Australians to clean usable water'. Currently, there are significant water restrictions in all the Australian mainland capital cities. In January 2007, the Prime Minister of Australia, announced a bold plan to rescue the Murray-Darling Basin. The plan incorporates political management changes, and an investment of $10Bn. Now is the time to develop improved techniques for management of water storage systems. This project will develop the fundamental mathematical principles required for this improved management.Read moreRead less