Multiple Sclerosis Therapy: Human Pluripotent Stem Cell-Derived Neural Precursor Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,775,225.00
Summary
Treatments for Multiple Sclerosis (MS) often have unsatisfactory outcomes. The limited ability of the body to repair damaged nerve tissue highlights a critically important need for MS patients. The long-term goal of our research is to develop a stem cell-based therapy that halts disease progression and repairs damaged nerve tissue. Research efforts will refine techniques to make safe and clinically-compatible cells from human stem cell lines and verify the therapeutic activity of these cells.
NOX Enzymes As Mediators Of Inflammation-triggered Neurodegeneration: Modulating NOX Enzymes As Novel Therapies
Funder
National Health and Medical Research Council
Funding Amount
$994,846.00
Summary
The NEURINOX project aims at identifying novel therapeutic targets for neurodegenerative diseases; an increasing health issue for the ageing Australian population. NADPH oxidases (NOX) enzymes, generate reactive oxygen species, and are key regulators of neuroinflammation. Inflammatory dysregulation is characterized by a change in NOX activity. NEURINOX will expound the links between neuroinflammation, NOX enzyme activity & neurodegenerative diseases to identify novel therapeutic targets to treat ....The NEURINOX project aims at identifying novel therapeutic targets for neurodegenerative diseases; an increasing health issue for the ageing Australian population. NADPH oxidases (NOX) enzymes, generate reactive oxygen species, and are key regulators of neuroinflammation. Inflammatory dysregulation is characterized by a change in NOX activity. NEURINOX will expound the links between neuroinflammation, NOX enzyme activity & neurodegenerative diseases to identify novel therapeutic targets to treat neuroinflammation.Read moreRead less