The Mechanisms Of Epithelial Cell Survival That Govern Thymus Function
Funder
National Health and Medical Research Council
Funding Amount
$620,967.00
Summary
The thymus is an organ dedicated to the production of crucial immune cells, called T lymphocytes. Cancer treatments, such as radiation or chemotherapy, destroy thymic function and impair immune recovery in patients. We aim to uncover molecular processes that govern the life and death decisions of cells in the thymus. Our goal is to then use this information to develop treatments to protect this critical organ from damage and improve immune recovery following radiation or chemotherapy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100030
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Test-bed for Wide-Area Software Defined Networking Research. Test bed for wide-area software defined networking research: This project aims to develop a wide-area test bed, spanning ten organisations, for conducting research and experimentation in the emerging disruptive technology of Software Defined Networking (SDN). SDN is likely to bring long-term transformation to the networking industry, much like cloud computing did, by enabling dynamic virtualised elastic network services under software ....Test-bed for Wide-Area Software Defined Networking Research. Test bed for wide-area software defined networking research: This project aims to develop a wide-area test bed, spanning ten organisations, for conducting research and experimentation in the emerging disruptive technology of Software Defined Networking (SDN). SDN is likely to bring long-term transformation to the networking industry, much like cloud computing did, by enabling dynamic virtualised elastic network services under software control. The test bed will empower Australian researchers in network technologies and dependent applications (for example, multimedia and security) to collaboratively develop and demonstrate novel ideas at scale. This is expected to benefit Australia by giving our researchers international recognition in this nascent area, and developing a national talent pool for local industry.Read moreRead less
Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
Genetic Programs Orchestrated By AP-1 Transcription Factors In Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$599,941.00
Summary
Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.
Ultrahigh-speed optical transport for sustaining the internet growth. Our society has entered an information era centred around the Internet. This project aims to study novel transport technologies to construct optical backbone networks supporting the Internet traffic. The project will keep Australia at the leading edge of exciting Terabit technologies as well as create commercial opportunities in Australia.
Few-mode transmission: harnessing the capacity of optical fibres. Optical fibres are widely deployed for carrying internet traffic. This project aims to study breakthrough technologies to dramatically increase the capacity of optical fibres. The project will help maintain Australia at the leading edge of the information age as well as providing exciting opportunities for training research associates and students.
Classifying Internet traffic for security applications. As the internet traffic data exponentially increases every year, traffic classification has become a fundamental approach to the security of the Internet. This project aims to develop a set of novel techniques for internet traffic classification, which is fundamentally important to defend against the serious cyber-attacks and effectively minimise the damages. This project is significant as it can help to improve cyber security, which is ess ....Classifying Internet traffic for security applications. As the internet traffic data exponentially increases every year, traffic classification has become a fundamental approach to the security of the Internet. This project aims to develop a set of novel techniques for internet traffic classification, which is fundamentally important to defend against the serious cyber-attacks and effectively minimise the damages. This project is significant as it can help to improve cyber security, which is essential for the work and daily lives of the Australian people. Furthermore, the proposed models and techniques will be important for enhancing the protection of Australian critical infrastructures against malicious cyber-attacks.Read moreRead less
Self-coherent detection for data centre. This project aims to explore the architecture of terabit data transport using self-coherent detection that addresses the tight constraints of power, space and cost in data centres. The project expects to create new knowledge in coherent detection based on optical equalisation rather than conventional power-hungry electronic equalisation. Expected outcomes of this project include advanced architecture of polarisation effect equalisers and all-optical equal ....Self-coherent detection for data centre. This project aims to explore the architecture of terabit data transport using self-coherent detection that addresses the tight constraints of power, space and cost in data centres. The project expects to create new knowledge in coherent detection based on optical equalisation rather than conventional power-hungry electronic equalisation. Expected outcomes of this project include advanced architecture of polarisation effect equalisers and all-optical equalisation algorithms as well as enhanced international collaboration with top experts in optical communications. The outcomes will contribute to maintaining Australia’s high reputation in the ICT arena.Read moreRead less
The road to Terabit Era: the optical transport perspective. The Internet has been playing an increasingly critical role in today's society. The project aims to look into novel approaches to construct the physical layer of optical internet networks. The project will keep Australia in the leading edge of exciting Terabit transport technologies as well as create many commercial opportunities in Australia.
Mechanistic Basis Of AP-1-regulated Gene Expression During Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$597,802.00
Summary
The spread of colorectal cancers in the body poses a major clinical problem for which current treatment options are inadequate. This project aims to unravel how a specific DNA-binding protein regulates the expression of genes involved in the spread of these cancers. The research is expected to provide a better mechanistic understanding of how disease progression occurs and to identify novel strategies to treat aggressive tumours.