Molecular Regulation Of Eosinophil Production: A Basis For Intervention In Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$609,281.00
Summary
Eosinophils are rare blood cells that play a key role in the pathology of asthma and other inflammatory diseases. Asthma afflicts hundreds of millions of people worldwide, and excess eosinophils are common in many patients. We aim to define the cells involved in eosinophil development, and we will use cutting-edge technologies to identify new eosinophil regulators that may serve as drug targets or as novel entry points for development of therapeutics for asthma or other inflammatory diseases.
S100 Proteins: Novel Oxidant Scavengers In Allergic Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$505,814.00
Summary
Allergic inflammation includes conditions such as dermatitis and asthma. Asthma, affects one in 10 adults and one in 6 Australians, costing ~$720 million/annum. We will characterize new mediators of oxidant defence which have suppressive effects on key pathogenic processes. The novel oxidative changes in S100 proteins may lead to new diagnostic reagents and new strategies for therapy. Results will open new frontiers in asthma biology and will apply to other chronic inflammatory diseases.
Effect Of A Four-food Elimination Diet In Children With Eosinophilic Oesophagitis – A Multi-centre, Randomised Controlled Trial And Investigation Of Disease Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$538,792.00
Summary
Eosinophilic oesophagitis (EO) is a recently recognised form of allergic inflammation in the oesophagus. EO is increasingly common in childhood and often linked to food allergy. Its treatment in children mainly relies on complex elimination diets or a liquid elemental formula which may require tube feeding due to poor taste. This Australian multi-centre trial will assess the effects of a four-food elimination diet in children with EO and will investigate novel disease mechanisms.