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Growth Factors And Their Effect On MicroRNAs And Transcription Factors In Tubulointerstitial Fibrosis In Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$490,202.00
Summary
A common cause of kidney disease is diabetes and is partly related to increased expression and action of growth factors such as CTGF. These factors promote the deposition of scar tissue in the kidney by acting on a novel class of intracellular regulator molecules called microRNAs, to change the cell's characteristics such that cells begin laying down excess collagen. This proposal will focus on how growth factors act on microRNAs and the role of microRNAs in diabetic kidney disease.
The Transcription Factor ZNF652: Deciphering Its Role In Breast Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$342,996.00
Summary
From our continuing research we have shown a protein called ZNF652 is involved in cancer. This proposal focuses on the role of this gene in the spread of cancer within the breast and to other organs. We will determine its role in a process where a cancer cell changes its characteristics to make it more likely to spread to other tissues. Our preliminary results suggest ZNF652 could be a marker that will predict poor prognosis. This proposal will further investigate this finding.
Regulation Of Expression Of MicroRNAs Involved In EMT
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
The majority of deaths from cancer are due to metastasis, which involves cancer cells becoming invasive and migratory. We aim to understand the molecular mechanisms that control this process, which may lead to identification of molecules that are potentially useful for diagnosing and treating cancer metastasis. We will investigate how TGF� regulates the expression of ZEB proteins, how the ZEB proteins function to repress key microRNAs, and what other genes are targeted by the ZEBs.
Regulation Of Expression Of The MicroRNA-200 Family
Funder
National Health and Medical Research Council
Funding Amount
$573,557.00
Summary
The majority of deaths from cancer are due to tumour metastasis. To metastasize, tumour cells must convert to a migratory form that can allow tumor cells to migrate and disseminate in the body. This process requires a genetic reprogramming of the cell. We have discovered that this genetic reprogramming is under the control of small RNA molecules called microRNAs. In this project we investigate what controls the levels of the microRNAs, to allow metastasis to occur in colon tumours.