Optimising Accuracy And Cost-Effectiveness Of Screening For Pulmonary Arterial Hypertension In Scleroderma
Funder
National Health and Medical Research Council
Funding Amount
$375,403.00
Summary
Scleroderma is one of the most devastating diseases of the immune system. With features that affect every organ in the body, scleroderma shortens the average patient’s life by over three decades. Pulmonary arterial hypertension (PAH), a condition of increased resistance in the blood vessels of the lungs, is the major cause of death in this disease. The purpose of this project is to develop a new 'screening' model for the early detection of PAH in scleroderma, thereby enabling earlier initiation ....Scleroderma is one of the most devastating diseases of the immune system. With features that affect every organ in the body, scleroderma shortens the average patient’s life by over three decades. Pulmonary arterial hypertension (PAH), a condition of increased resistance in the blood vessels of the lungs, is the major cause of death in this disease. The purpose of this project is to develop a new 'screening' model for the early detection of PAH in scleroderma, thereby enabling earlier initiation of life-saving treatment.Read moreRead less
Early Detection And Treatment Of Rheumatic Heart Disease In High Risk Communities Using Community-led Approaches For Active Case Finding, Education And Engagement In Care
Funder
National Health and Medical Research Council
Funding Amount
$358,752.00
Summary
Rheumatic heart disease (RHD) affects many Aboriginal and Torres Strait Islander people. Early detection using an ultrasound of the heart (called an “echo”) can help children access treatment. Echo screening in remote communities needs active community participation and leadership in order to succeed. I will study new approaches to community-led echo screening to see if they are accurate enough, evaluate the impact of community involvement and describe outcomes for those diagnosed with RHD.
Cardiac Dysfunction In Advanced Liver Disease And After Liver Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Heart disease is the leading cause of early death after liver transplantation (LT). The scarcity of donor organs means that LT is a limited and valuable resource. We propose screening for heart disease before LT by CT scanning of heart arteries and heart function on stress testing to improve detection of coronary heart disease (CHD). Follow-up CT scans will also assess if LT causes progression of CHD. These studies will aid in development of personalised treatment strategies to improve outcomes.
Longitudinal Mechanics Of The Peri-Infarct Zone And Ventricular Tachycardia Inducibility In Patients With Chronic Ischaemic Cardiomyopathy
Funder
National Health and Medical Research Council
Funding Amount
$438,449.00
Summary
Ischaemic heart disease is a major cause of death in developed countries. Sudden cardiac death is precipitated by lethal irregularities in heart rhythm that originate around the scar tissue that forms within the heart after a heart attack. This study�s aim is to investigate the role of new ultrasound technologies in characterising the heart tissue where fatal cardiac arrhythmias arise. We hope that these novel imaging tools will help to identify individuals whose lives may be saved by appropriat ....Ischaemic heart disease is a major cause of death in developed countries. Sudden cardiac death is precipitated by lethal irregularities in heart rhythm that originate around the scar tissue that forms within the heart after a heart attack. This study�s aim is to investigate the role of new ultrasound technologies in characterising the heart tissue where fatal cardiac arrhythmias arise. We hope that these novel imaging tools will help to identify individuals whose lives may be saved by appropriate preventative measures.Read moreRead less