Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Engagement in early childhood education in the context of disadvantage. This research responds to enduring inequalities in children’s participation in high quality early childhood education and care (ECEC). Contemporary families face precarious labour markets and a childcare system with stringent workforce participation requirements. This project will illuminate the affordances of everyday life for families most challenged by these emergent conditions and develop understandings of how to calibr ....Engagement in early childhood education in the context of disadvantage. This research responds to enduring inequalities in children’s participation in high quality early childhood education and care (ECEC). Contemporary families face precarious labour markets and a childcare system with stringent workforce participation requirements. This project will illuminate the affordances of everyday life for families most challenged by these emergent conditions and develop understandings of how to calibrate services accordingly. Findings will support universal ECEC access through knowledge translation about contemporary disadvantage to policy and practice forums. A strong Indigenous component contributes to researcher training and knowledge about effective practice for Indigenous children and their families.Read moreRead less
Diseases of the 21st century are complex with environmental and genetic causes. At the interface of these is Epigenetics - factors not specified by DNA sequence that control genes. Recent data show much of the risk associated with disease is set early in life, even during the time in the womb. The MCRI CDDE laboratory has assembled teams of researchers of diverse expertise investigating epigenetics of human development and complex disease to hopefully prevent or reverse them early in life.
Mental Health Of Young People With Developmental Disabilities
Funder
National Health and Medical Research Council
Funding Amount
$5,622,916.00
Summary
Mental health problems of people with developmental disabilities are a substantial public health problem. A large Australian study shows that the problem begins early and persists without intervention. We will evaluate the Stepping Stones Triple P model of parenting early intervention after adding newly developed modules for specific causes of ID. The effectiveness of the program across three states will be evaluated.
Motor Functioning In Autism And Asperger's Disorder: Furthering Current Neurobehavioural And Clinical Definitions
Funder
National Health and Medical Research Council
Funding Amount
$354,932.00
Summary
While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isol ....While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isolated and rejected from the peer group. Also, hand writing problems have a significant impact on children's academic performance. Our previous research has suggested that there may be particular patterns of motor problems that characterise individuals with autism and Asperger's disorder. Our proposed research aims to use the kinds of 3D motion analysis technology used in the movie industry to capture exactly how people affected by these conditions move and respond to the environment. This study will enable us to highlight particular parts of the brain-motor circuitry that are affected by these disorders and will also enable us to more clearly distinguish how autism is different from Asperger's disorder. Ultimately, it is hoped that our motor investigations will lead to improved assessment and interventions for these disorders.Read moreRead less
Rural-Urban Migration in China and Indonesia: Patterns, Consequences and Policy Intervention. China and Indonesia are two of Australia's most important neighbours. Their process of economic development and the social and political stability have tremendous impact on Australia's economic performance and prosperity. Assisting China and Indonesia to effectively manage the unprecedented large scale rural-urban migration is consistent with Australia's own interest. This project will lead to important ....Rural-Urban Migration in China and Indonesia: Patterns, Consequences and Policy Intervention. China and Indonesia are two of Australia's most important neighbours. Their process of economic development and the social and political stability have tremendous impact on Australia's economic performance and prosperity. Assisting China and Indonesia to effectively manage the unprecedented large scale rural-urban migration is consistent with Australia's own interest. This project will lead to important policy analyses that help the effective and efficient allocation of Australia's development aid budget. It will also build research and policy collaborations and cross-fertilisation amongst Australian government agencies, the Chinese government agencies in Indonesia as well as domestic and international research institutes.Read moreRead less
Young children in digital society: An Online Tool for service provision . This project aims to identify the practices enacted and shared amongst young children, their families and educators in digital society.The project is significant because in digital society families and educators face new demands ensuring technologies are used in the best interests of young children. Knowledge about practices in digital society informs adult decision-making using technologies with, by and for young children ....Young children in digital society: An Online Tool for service provision . This project aims to identify the practices enacted and shared amongst young children, their families and educators in digital society.The project is significant because in digital society families and educators face new demands ensuring technologies are used in the best interests of young children. Knowledge about practices in digital society informs adult decision-making using technologies with, by and for young children in the early years. The outcome is a new Online Tool for the Partner Organisations to share exemplar practices benefiting Australian children, their families and educators with new resources, materials and programs in areas including: digital media production, cyber-safety education, digital play and digital parenting.
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The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.