Driving health care efficiencies and patient care outcomes by improving communication in acute to primary transitions of care. Communication problems are a major contributor to poor outcomes for patients transferring from acute to primary care, accounting for 41 per cent of preventable hospital readmissions. This project aims to identify risk factors for readmission and barriers to successful transitions of care for high-risk patient groups (including the elderly, paediatric and mental health pa ....Driving health care efficiencies and patient care outcomes by improving communication in acute to primary transitions of care. Communication problems are a major contributor to poor outcomes for patients transferring from acute to primary care, accounting for 41 per cent of preventable hospital readmissions. This project aims to identify risk factors for readmission and barriers to successful transitions of care for high-risk patient groups (including the elderly, paediatric and mental health patients), it will then apply these findings to provide effective, measurable and cost-efficient protocols to improve discharge transition outcomes for patients, carers and health service providers. Research outcomes will have general relevance to Australian healthcare settings and include the development of ‘The Safe Transition Communications Tool.’Read moreRead less
Soft nanotubes for biomedical applications. Nature employs self-assembly of small molecules to build complex materials. This project will mimic natural self-assemblies to design synthetic tubular structures on the nanoscale, and apply these nanostructures to solve problems in the fields of biology and medicine.
Discovery Early Career Researcher Award - Grant ID: DE120100295
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Computational modelling of nanostructures designed to mimic ion-selective biological channels. The project aims to design nanotubes (hollow tubes with nanometre diameters) constructed from various materials, such as carbon, to broadly mimic biological ion channels. This research will facilitate the development of efficient desalination membranes, potent antibiotics and pharmaceutical products for treatments of cancer and cystic fibrosis.
Biogenesis of the relict plastid of Apicomplexan parasites: the role of a dynamin-related protein in apicoplast division. The Apicomplexa are a group of intracellular parasites that cause several important diseases. Most Apicomplexa contain an organelle called the apicoplast that is indispensable for their survival and that can only form through the division of pre-existing apicoplasts. This project will examine the molecular mechanisms of how this process occurs.
Synthesis of chemically well-defined and biocompatible oligopyrroles for tissue engineering applications. Modern methods of synthesis will be used to prepare chemically well-defined and structurally novel materials capable of facilitating the regeneration of damaged nerves and bone structures. This should lead to new means for treating degenerative diseases and major injuries, events that impact on hundreds of thousands of Australians each year.
Subject-specific computational models for accurate evaluation of muscle function in human locomotion. The purpose of this project is to advance current understanding of muscle function during human locomotion. The most significant outcome will be the development of novel computational tools that can play a pivotal role in the healthcare industry through the prevention, diagnosis and treatment of movement disorders.
Evaluating viscum album in tumour eradication strategies. Extracts from the plant parasite mistletoe are, internationally, the most widely used complementary cancer treatments. Providing clear evidence-based research, this project will focus on enhancing mistletoe anti-cancer treatment through the development of novel liposome-based tumour therapies.
Building models for complex data. The purpose of this project is to better understand the process of building statistical models and construct new methods for building models for particular kinds of complex data. The expected outcomes include a new way of thinking about model building and practical tools which together enable us to get more value out of analysing complex data.
Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This ....Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This project aims to build on recent discoveries of new stimuli to implement objective tests with which to study structure vision with the Partner Organisation. The project aims to also expand on realistic models of how Structure Vision may be computed by just a few coupled cortical pyramidal cells.Read moreRead less
Chemically re-engineering bioactive natural products using fragment based drug design. Current drug and agrichemical discovery technologies are under immense pressure to meet the future pharmaceutical and agriculture demand created by population growth. This project will develop a novel technology concept that re-engineers the chemical features of bioactive natural products optimising medicine and agrichemical discovery.