Defining The Mechanisms By Which ABCA7 And ApoE Control Alzheimer's Disease Risk. Functional Characterisation Of New Therapeutic Targets For Dementia Prevention And Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$687,975.00
Summary
Alzheimer’s disease (AD) is the major cause of dementia and is currently without a curative treatment. An understanding of the pathways that lead to AD is urgently required to develop approaches for treatments. We have discovered new pathways by which proteins called ApoE and ABCA7 control AD. We now aim to define precisely how these proteins work in the brain and use this information to develop therapeutic approaches to treat AD in humans.
This work will analyse how cells, the building blocks of tissues, are organized together to form functioning organs. It focuses on the adhesion molecules that allow cells to recognize one another, which cooperate with the internal skeleton of cells to link them together. We aim to understand how these cellular systems work normally and how they are targeted to disrupt tissue integrity in diseases like cancer and inflammation.
Addressing Evidence-practice Gaps To Improve Maternal And Child Health Outcomes In Vulnerable Populations
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
The overall goal of this fellowship program is to contribute to ‘closing the gap’ in maternal and child health outcomes in Indigenous, refugee and other vulnerable and socially disadvantaged population groups by working at the interface of policy, health services and community to co-design and implement policy-relevant research needed to achieve sustained improvements in maternal and child health outcomes.
A Translational Model For Indigenous Mental Health
Funder
National Health and Medical Research Council
Funding Amount
$949,893.00
Summary
This Fellowship will be supporting research into indigenous psychosocial wellbeing, as well as the psychological health of refugees and people living in post-conflict settings.
The proposed program of research consists of (i) conducting a new trial to examine feasible and relatively low-cost physical activity promotion programs for adults with pre-diabetes; (ii) completing a series of existing major-funded studies relating to health promotion and education programs to promote physical activity; and (iii) I will serve as the Director for the University of Newcastle’s recently-funded Priority Research Centre in Physical Activity and Nutrition.
Innovative Health Programs To Reduce Inequality In Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
As part of his Senior NHMRC Fellowship, Prof Simon Stewart, a world-renowned health services researcher, will lead an internationally linked team of researchers from a broad range of health disciplines to undertake a program of research designed to improve the lives of those most vulnerable to heart disease and poor health outcomes. His program of research will focus on Indigenous Australians, patients with complex forms of heart disease and urban African communities in economic transition.
I am a health economist at the George Institute for Global Health. My application will enable me to lead a program of research in three major themes, involving numerous collaborations in Australia and overseas: 1) the economic impact of chronic illness on households; 2) community preferences in health care and; 3) cost effectiveness studies. The program also includes policy engagement and significant training and development in health economics – an area of recognised skills shortage.
Leveraging Women’s Health Data Resources To Reduce Chronic Disease Risk And Extend Healthspan
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Chronic diseases, such as osteoporosis and asthma, pose serious risks for Australian women. Reproductive health is central to women’s use of health services across life and is linked with the risk of chronic diseases. This research will build on two decades of linked data in Australia’s leading study of women’s health. It aims to guide development of women’s use of reproductive and maternal health services as an opportunity to prevent chronic diseases and improve long-term health.
Reducing Disparities In Heart Disease-Related Morbidity And Mortality: Optimising Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart di ....Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart disease in these vulnerable groups.Read moreRead less