Genetic Mechanisms That Moderate Effects Of Aβ Accumulation In Preclinical Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$603,525.00
Summary
Alzheimer’s disease (AD) is the most common form of dementia, and the number of people living with it will triple by 2050. There is currently no cure for AD, and the only means of slow the growing epidemic is to delay onset. We propose to understand the complex interplay between genetic, cognitive, neuroimaging and biological markers of AD in order to better understand the disease process, and in turn identify high-risk individuals for clinical trials and uncover disease-modifying strategies.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
The Role Of Renal Dendritic Cells In Infection And Immunity Under Immunosuppression
Funder
National Health and Medical Research Council
Funding Amount
$475,143.00
Summary
Kidney transplantation is the best treatment for kidney failure but it is frequently complicated by bacterial and viral infections that can cause rejection and may cause loss of the kidney. This grant will study the role that dendritic cells in the kidney play in causing rejection and preventing infection. With the knowledge gained from these studies, we will be able to discover new ways to prevent rejection and treat infections of the kidney post transplant.
Discovery Early Career Researcher Award - Grant ID: DE230100652
Funder
Australian Research Council
Funding Amount
$407,500.00
Summary
Toward data justice in Australian schools. This project will investigate the challenges raised by digital data for Australian schools. The use of digital technologies in schools has led to systematic data collection, which reconfigures schooling processes and interpersonal relationships and presents new risks to staff and students. Although there are laws in place to protect students' rights, there are hidden consequences to using digital technologies. This research project investigates how data ....Toward data justice in Australian schools. This project will investigate the challenges raised by digital data for Australian schools. The use of digital technologies in schools has led to systematic data collection, which reconfigures schooling processes and interpersonal relationships and presents new risks to staff and students. Although there are laws in place to protect students' rights, there are hidden consequences to using digital technologies. This research project investigates how data collection, use and disclosure is experienced and understood in schools. It will identify the role played by intermediaries, such as tech brokers, educational authorities and professional networks. Benefits include policy recommendations, protocols and guidelines for data justice in schools.Read moreRead less
New Generation of High-Performance Radio Frequency Devices . The strong demand for faster internet speed pushes high-speed technology to evolve faster. Designing and developing devices are now facing changes that are far more complex. We aim to tackle them, proposing to develop phase-change materials-based electronic systems. The outcomes will be reconfigurable devices with unprecedentedly increased operational frequency, reduced critical system-level metrics, and elimination of control circuits ....New Generation of High-Performance Radio Frequency Devices . The strong demand for faster internet speed pushes high-speed technology to evolve faster. Designing and developing devices are now facing changes that are far more complex. We aim to tackle them, proposing to develop phase-change materials-based electronic systems. The outcomes will be reconfigurable devices with unprecedentedly increased operational frequency, reduced critical system-level metrics, and elimination of control circuits. The successful results will address the Science and Research Priority of Modern Manufacturing and bring substantial socio-economic benefits to Australia by executing advancements of new technologies for modern wireless communications, leading to new high-tech opportunities, jobs, and economic growth.Read moreRead less
Implementation and evaluation of a program to reduce alcohol and related problems among farm men and women. Farming is pivotal to Australia's food production and economy; yet farm communities are under great stress. The Sustainable Farm Families program aims to strengthen rural communities across Australia, and our project will add an important component to it by producing an evidence-based strategy for encouraging farm men and women to adopt more positive alcohol-related behaviours that will l ....Implementation and evaluation of a program to reduce alcohol and related problems among farm men and women. Farming is pivotal to Australia's food production and economy; yet farm communities are under great stress. The Sustainable Farm Families program aims to strengthen rural communities across Australia, and our project will add an important component to it by producing an evidence-based strategy for encouraging farm men and women to adopt more positive alcohol-related behaviours that will lead to better physical and mental health. We expect that our project will reduce the level of dangerous alcohol consumption and enhance the economic, social and cultural fabric of rural Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101422
Funder
Australian Research Council
Funding Amount
$467,132.00
Summary
Co-creating critical health literacy interventions. This project aims to enhance critical health literacy in culturally and linguistically diverse communities in western Sydney. Never in history has there been such an abundance of health information from numerous sources, with varying degrees of trustworthiness. This project intends to work with communities to co-create scalable interventions which promote critical health literacy and support people to navigate and appraise the sea of available ....Co-creating critical health literacy interventions. This project aims to enhance critical health literacy in culturally and linguistically diverse communities in western Sydney. Never in history has there been such an abundance of health information from numerous sources, with varying degrees of trustworthiness. This project intends to work with communities to co-create scalable interventions which promote critical health literacy and support people to navigate and appraise the sea of available health (mis)information. This project expects to provide significant social and health benefits through the development of innovative health literacy research methods for use with culturally-diverse communities and scalable interventions with the capacity to enhance critical skills across communities.Read moreRead less
Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of ma ....Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of marketing strategies used to sell sports wagering in Australia; important qualitative insights into the impact of these marketing strategies on gambling behaviours; and, recommendations for a comprehensive public health approach to help counter the potential long and short term risks associated with sports wagering marketing.Read moreRead less
Development of a comprehensive model and programmed intervention for emotion processing deficits in childhood-onset mental health problems. This research is in the National Research Priority, promoting and maintaining good health. Mental health problems cost Australia millions of dollars every year as well as creating immeasurable social adversity for individuals and families. The proposed research represents a significant step towards reducing these costs and improving the effectiveness of earl ....Development of a comprehensive model and programmed intervention for emotion processing deficits in childhood-onset mental health problems. This research is in the National Research Priority, promoting and maintaining good health. Mental health problems cost Australia millions of dollars every year as well as creating immeasurable social adversity for individuals and families. The proposed research represents a significant step towards reducing these costs and improving the effectiveness of early intervention and prevention. The research will lead to improvements in methods for early detection of child psychopathology with potential for implementation in both community health and educational services nation-wide. The research partnership will build Australia's capacity for innovative research in the development, early intervention and treatment of mental health problems.Read moreRead less
A study of contemporary family, social and cultural influences on first-time mothers' decisions about infant feeding and early parenting practices. Children who are never breastfed are more likely to experience respiratory infections, gastroenteritis, diabetes and as adults, high blood pressure, obesity and type-2 diabetes. This study of infant feeding decision-making in first-time mothers will inform strategies, grounded in the daily lives of women and families to assist mothers to breastfeed f ....A study of contemporary family, social and cultural influences on first-time mothers' decisions about infant feeding and early parenting practices. Children who are never breastfed are more likely to experience respiratory infections, gastroenteritis, diabetes and as adults, high blood pressure, obesity and type-2 diabetes. This study of infant feeding decision-making in first-time mothers will inform strategies, grounded in the daily lives of women and families to assist mothers to breastfeed for longer particularly in communities where breastfeeding is not the norm. Increased support for breastfeeding women from family, community and health professionals is likely to reduce the distress reported by many new mothers. Strategic application of findings will lead to health gains from increased breastfeeding and translate into significant cost savings for the Australian health system. Read moreRead less