Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
The impact of environmental change on larval energetics of molluscs on the southeast coast of Australia. This project will investigate the impact of environmental change on larval energetics of molluscs on the southeast (SE) coast of Australia. The SE coast of Australia is a climate hotspot characterised by rising ocean temperatures, fluctuations in salinity and we expect in the near future ocean acidification (OA). Mollusc larvae show extreme sensitivity to OA, but the impacts of other stressor ....The impact of environmental change on larval energetics of molluscs on the southeast coast of Australia. This project will investigate the impact of environmental change on larval energetics of molluscs on the southeast (SE) coast of Australia. The SE coast of Australia is a climate hotspot characterised by rising ocean temperatures, fluctuations in salinity and we expect in the near future ocean acidification (OA). Mollusc larvae show extreme sensitivity to OA, but the impacts of other stressors remains unknown. It is predicted that OA will reduce the capacity of larvae to cope with temperature and salinity, particularly when food supply is low and in populations which have had no previous exposure to OA. Understanding the response of mollusc larvae to environmental change will support ecologically and economically significant mollusc populations over this century.Read moreRead less
Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the ....Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the full productivity benefits of increased CO2 and when this will happen. This should improve predictions of carbon exchange and indicating the best direction for climate change adaptation measures.Read moreRead less
Optimising feeds to support ecosystem-based aquaculture. This project aims to assess the global and local consequences of changing feeds in aquaculture by developing a new interdisciplinary sustainability assessment framework. The project expects to generate new methods to understand and predict local farm-to-ecosystem changes and global environmental footprints under contrasting feed and climate scenarios by integrating field data with novel experiments, modelling techniques and global mapping ....Optimising feeds to support ecosystem-based aquaculture. This project aims to assess the global and local consequences of changing feeds in aquaculture by developing a new interdisciplinary sustainability assessment framework. The project expects to generate new methods to understand and predict local farm-to-ecosystem changes and global environmental footprints under contrasting feed and climate scenarios by integrating field data with novel experiments, modelling techniques and global mapping of terrestrial and marine feed raw materials and their impacts. Expected outcomes include new methods to assess ecological, social and economic trade-offs under different feeds to inform decision making in support of an ecosystem-based approach to aquaculture spanning global to local scales.Read moreRead less
Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working ....Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working with monitoring authorities throughout Australia, we will produce a specific, sensitive and cost-effective technology that will ultimately be applicable worldwide. Read moreRead less
Does fire control vegetation in the Tasmanian World Heritage Area? Aims: This project aims to discriminate between competing explanations for vegetation patterns in the Tasmanian Wilderness World Heritage Area: (a) fire (the legacy of Aboriginal burning), or (b) soil. We will do this through a novel, transdisciplinary research program.
Significance: The project expects to create new knowledge essential for achieving evidence-based fire management, as well as to advance a globally important ecol ....Does fire control vegetation in the Tasmanian World Heritage Area? Aims: This project aims to discriminate between competing explanations for vegetation patterns in the Tasmanian Wilderness World Heritage Area: (a) fire (the legacy of Aboriginal burning), or (b) soil. We will do this through a novel, transdisciplinary research program.
Significance: The project expects to create new knowledge essential for achieving evidence-based fire management, as well as to advance a globally important ecological theory.
Outcomes: Expected outcomes include significantly strengthened fire science and fire management capacity in Tasmania.
Benefit: Benefits should include the protection of globally significant cultural, biological and landscape values that sustain the vibrant Tasmanian tourist economy.Read moreRead less
In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually as ....In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually associated with fabrication and miniaturisation. A simple photo-grafting process, initiated by UV light can be used for the selective chemical modification of these materials. These tailored monoliths can then be used for the in-line coupling of biological sample handling and capillary electrophoresis (CE) for the determination of drugs and related metabolites in biological fluids, thus avoiding time-consuming and costly off-line sample pre-treatment. This will lead to the development of new methods for the rapid determination of drugs, metabolites and other small molecules in clinical samples.Read moreRead less
Grazing-fire interactions and vegetation dynamics. Grazing and fire are the two major cost-effective tools that can be used to manipulate the vegetation of reserves and rangelands. This project will result in information and models that will enable a more effective use of grazing than at present in natural vegetation management for both nature conservation and production. An understanding of the ways in which vertebrate grazing animals influence the incidence and intensity of fire is also highly ....Grazing-fire interactions and vegetation dynamics. Grazing and fire are the two major cost-effective tools that can be used to manipulate the vegetation of reserves and rangelands. This project will result in information and models that will enable a more effective use of grazing than at present in natural vegetation management for both nature conservation and production. An understanding of the ways in which vertebrate grazing animals influence the incidence and intensity of fire is also highly important in planning to prevent the occasional vegetation fire that causes substantial losses of life, property and conservation values, especially in the context of predicted climatic change.Read moreRead less
Gauging the value of flexible learning options for disenfranchised youth and the Australian community. Investment in flexible learning options (FLOs) for young people who have disengaged from schooling requires understanding of how they work and evidence about their economic and social value. This project will provide both through innovative and integrated methods, analysing FLO sites across three Australian states and the Northern Territory.