Dynamics of eigenvalue/eigenspace algorithms with applications to signal processing. Many problems in signal and systems lead naturally to an eigenvalue/eigenspace determination and tracking problem; for example (acoustic) echo-cancellation, crosstalk suppression in ADSL modems, direction of arrival determination with an array of sensors, linear system identification etc. Exploiting methods from global analysis and dynamical systems theory we will study the available algorithms for eigenspace de ....Dynamics of eigenvalue/eigenspace algorithms with applications to signal processing. Many problems in signal and systems lead naturally to an eigenvalue/eigenspace determination and tracking problem; for example (acoustic) echo-cancellation, crosstalk suppression in ADSL modems, direction of arrival determination with an array of sensors, linear system identification etc. Exploiting methods from global analysis and dynamical systems theory we will study the available algorithms for eigenspace determination to characterise their computational efficiency, accuracy and effectiveness in various data scenarios. The analysis will lead to improved designs for eigenvalue/eigenspace algorithms, as well as design tools to engineer algorithms to specific situations.Read moreRead less
Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reductio ....Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reduction in arterial relaxin expression in older animals is a major cause of arterial stiffening. Further studies will investigate the mechanisms by which relaxin administration can alleviate this phenomenon.Read moreRead less
Automated Interaction Technologies for Mobile Hand-held Devices. This project is concerned with developing intelligent technologies that support human interaction through handheld devices, connected to wireless digital networks. Intelligent software assistants running on these devices will interact with one another in order to coordinate the activities of multiple users. Such automated coordination may facilitate scheduling of meetings, collaboration among different members of a team, and negoti ....Automated Interaction Technologies for Mobile Hand-held Devices. This project is concerned with developing intelligent technologies that support human interaction through handheld devices, connected to wireless digital networks. Intelligent software assistants running on these devices will interact with one another in order to coordinate the activities of multiple users. Such automated coordination may facilitate scheduling of meetings, collaboration among different members of a team, and negotiating conflicts that may arise between the activities of different connected users. This will enable context-dependent task support and coordination of workers involved in industrial applications involving mobility and dynamism.Read moreRead less
Development of Knowledge Discovery for High Dimensional Biomedical Data. The recent progress in experimental techniques of molecular genetics has made available a wealth of genome data and raised the interest for analysis of DNA sequences. As the human and mouse genome projects are in a phase of systematic sequencing, computational tools based on concepts used in science fields have recently played a prominent role. Significant contributions to this project will increasingly depend upon original ....Development of Knowledge Discovery for High Dimensional Biomedical Data. The recent progress in experimental techniques of molecular genetics has made available a wealth of genome data and raised the interest for analysis of DNA sequences. As the human and mouse genome projects are in a phase of systematic sequencing, computational tools based on concepts used in science fields have recently played a prominent role. Significant contributions to this project will increasingly depend upon original application and development of algorithms for the analysis of genomic data, and of the computational systems that support them. These challenges have fostered major progress in computer science, leading to collaborative research of global significance.Read moreRead less
Characterisation of insulin-independent glucose uptake mediated by guanine nucleotide-binding proteins (G-proteins) coupled receptors. This project will provide first class postdoctoral training for Dr Sato in the laboratory of A/Prof Bengtsson one of the pioneers in the field of cell metabolism. He will learn new approaches to the study of cell signalling including the use of ribonucleic acid interference (RNAi) technologies and of a series of functionally altered mutants of phosphatidylinosito ....Characterisation of insulin-independent glucose uptake mediated by guanine nucleotide-binding proteins (G-proteins) coupled receptors. This project will provide first class postdoctoral training for Dr Sato in the laboratory of A/Prof Bengtsson one of the pioneers in the field of cell metabolism. He will learn new approaches to the study of cell signalling including the use of ribonucleic acid interference (RNAi) technologies and of a series of functionally altered mutants of phosphatidylinositol (PI) 3-kinase that he will bring back to Monash University. A better understanding of the cell signalling mechanisms involved in glucose transport will be of enormous benefit in developing new approaches to the treatment of diseases such as type II diabetes.Read moreRead less
Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The ....Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The focus of the project is the study of thulium doped silica-based fibres for amplification in the 1460 to 1530 nm wavelength region. Read moreRead less
Smart Location Sensors for Emergency Responders. 1. It underpins the 2006 e-Government strategy with regards to spatially enabling Australian Government. This research will generate outputs to support this strategy. 2. It contributes to Australian national strategies for emergency management with regards to 'assuring the safety of emergency responders'. 3. It addresses fundamental constraints of positioning systems like GPS and provides the theoretical and practical models to take GPS into 'hars ....Smart Location Sensors for Emergency Responders. 1. It underpins the 2006 e-Government strategy with regards to spatially enabling Australian Government. This research will generate outputs to support this strategy. 2. It contributes to Australian national strategies for emergency management with regards to 'assuring the safety of emergency responders'. 3. It addresses fundamental constraints of positioning systems like GPS and provides the theoretical and practical models to take GPS into 'harsher' environments. The outcomes will expand the uses of GPS and facilitate growth across many Australian industries. 4. It will enhance the expertise and international profile of Australian researchers by offering an innovative solution to an internationally significant problem.Read moreRead less
Understanding how the brain uses sensory information to guide reaching and grasping movements. Reaching, grasping and manipulating objects are crucial aspects of our daily lives, which are performed so effortlessly that they tend to be taken for granted. We know however that these functions take a relatively long time to mature (think of a baby learning how to get an object), and that they can be impaired by brain lesions involving a region called the posterior parietal cortex. We also know that ....Understanding how the brain uses sensory information to guide reaching and grasping movements. Reaching, grasping and manipulating objects are crucial aspects of our daily lives, which are performed so effortlessly that they tend to be taken for granted. We know however that these functions take a relatively long time to mature (think of a baby learning how to get an object), and that they can be impaired by brain lesions involving a region called the posterior parietal cortex. We also know that this region has multiple subdivisions, but how exactly these interact in allowing the sensory information to guide arm and hand muscles is unknown. Discovering how this happens in terms of cellular interaction can have profound implications for the creation of new technologies such as artificial limbs and autonomous robots, and result in health benefits.Read moreRead less
Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will ....Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will be related to the properties of neurones in those areas and to those of individual input and output fibres. An optical imaging equipment will be acquired in 2004 using a recently awarded LIEF grant to the CI.Read moreRead less
Characterisation and fabrication of nanophotonic devices based on multi-layer stacks. The aim of this proposal is to continue the existing collaborative project on fabrication and characterisation of nanophotonic devices based on the multi-layer stack method. The project will integrate the state-of-the-art techniques in the respective collaborating universities to fabricate a nano-probe which can produce an evanescent field approximately four orders of magnitude stronger than that under the conv ....Characterisation and fabrication of nanophotonic devices based on multi-layer stacks. The aim of this proposal is to continue the existing collaborative project on fabrication and characterisation of nanophotonic devices based on the multi-layer stack method. The project will integrate the state-of-the-art techniques in the respective collaborating universities to fabricate a nano-probe which can produce an evanescent field approximately four orders of magnitude stronger than that under the conventional condition. This novel probe provides a key to the successful fabrication of innovative nanophotonic devices including photonic transistors, photonic circuits, high-density data storage disks and drives, nano-motors and biochips, which underpin biotechnology, information technology and optical computing technology.Read moreRead less