Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offsho ....Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offshore coral reefs have responded to increased pollution and whether this is the cause of the very devastating crown-of-thorn-starfish infestations. Understanding the long-term effects of land-based pollution on the ecology of coral reefs in the GBR will thus provide a scientific basis to help ensure that it has a sustainable future.Read moreRead less