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Obstructive sleep apnea (OSA) is one of the most common complications of obesity and is independently associated with a reduced quality of life and cardiovascular disease. This project aims to identify the underlying factors linking obesity with OSA by examining how weight loss surgery can improve these factors. These important findings will contribute greatly to our understanding of OSA pathophysiology and are necessary to find better treatments for obesity-associated OSA.
Combined Therapy To Ameliorate Ventilatory Instability In Patients With Heart Failure And Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$386,648.00
Summary
Sleep apnea is highly prevalent, particularly in patients with heart failure, and treatment remains limited to applying pressure via a face mask which can be intolerable. Although instability in breathing control is a major cause of apnea in many patients, treatments targeting instability with sufficient efficacy are unavailable. This project will combine two treatments, acetazolamide and oxygen, to powerfully reduce instability and provide relief from sleep apnea in a subgroup of patients.
The Potential Of Blocking Translation Initiation For Cancer Therapy
Funder
National Health and Medical Research Council
Funding Amount
$347,792.00
Summary
Treatment of many cancers remains unsatisfactory and new drugs for treating them are urgently required. By determining how a new class of anti-cancer drugs kills cancer cells and whether they might also affect normal cells, we can determine how they can be optimally given to patients suffering from cancer.
Identification And Characterisation Of Novel Genetic Alterations In High Risk Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$315,336.00
Summary
Acute lymphoblastic leukaemia (ALL) remains the leading cause of cancer-related death in children and young adults. The goal of this research is to identify genetic abnormalities that contribute to treatment failure in high-risk ALL. In addition to providing insights into the biologic basis of ALL, this work has the potential to result in new diagnostic tests, predict response to chemotherapy, and identify new strategies to improve the treatment outcome for ALL patients.
Pharmacological Investigation Of The Glucagon-Like Peptide-1 Receptor (GLP-1R)
Funder
National Health and Medical Research Council
Funding Amount
$367,948.00
Summary
Family B G protein-coupled receptors represent key therapeutic targets for many conditions, including metabolic, bone, growth and neuronal disorders. However, poor mechanistic understanding of this receptor family impacts on their clinical value. Consequently, this research is aimed at gaining a more comprehensive understanding of the structure and function of the family B glucagon-like peptide-1 receptor through use of new and novel pharmacological techniques.
The body’s normal function depends upon maintaining energy balance matching demand and supply. The body senses its energy status by monitoring metabolite concentrations. I have discovered a metabolite that controls multiple enzymes critical for energy homeostasis and appetite in the body that may provide new approaches to tackle obesity related disease. I have found the metabolite-binding pocket in many proteins and it may represent a major new regulatory network.
Linking Estrogens, Prostatitis And Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$291,309.00
Summary
Prostatitis is very common and a significant health issue that affects men from their 20's. Estrogens promote inflammation and inflammation is associated with the development of cancer. If this study links estrogens, prostatitis and prostate cancer, we can provide better treatment for prostatitis, thus preventing progression to prostate cancer