Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Structure And Function Of Antimicrobial Therapies And Their Interaction With Upper Respiratory Biofilms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Bacterial infections of the upper respiratory tract are a major public health problem affecting millions of Australians. Commonly prescribed antibiotics are often not able to eradicate all bacteria as the bacteria often reside in a protective, self-produced gel-like matrix known as biofilm. This Fellowship aims to unravel the interaction of modern anti-infective therapeutics with the biofilm for the development of the next generation of safe and efficacious anti-biofilm strategies.
Managing and Mining Evolving Ontologies through combining Patterns Languages and Data Mining. Data mining offers insight into the substantial and growing repositories of medical data while pattern languages offer the ability to provide a high level conceptual designs of an artifact or process. This project thus promises to facilitate, on the one hand, the discovery of medical knowledge from large quantities of clinical or epidemiological data, while also providing a better way of constructing a ....Managing and Mining Evolving Ontologies through combining Patterns Languages and Data Mining. Data mining offers insight into the substantial and growing repositories of medical data while pattern languages offer the ability to provide a high level conceptual designs of an artifact or process. This project thus promises to facilitate, on the one hand, the discovery of medical knowledge from large quantities of clinical or epidemiological data, while also providing a better way of constructing and validating medically oriented design patterns which can then be used in medical data collection systems.Read moreRead less
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
Normalizing XML Documents. Our work will be of great benefit, both to the research community and to the ICT industry. The project addresses one of the most important problems in XML usage and we expect our results to be published in important international forums, as has our preliminary research on the topic. This will significantly improve Australia's reputation in research in the ICT area. In the longer term, we intend to build commercial software tools based on the results of our research ....Normalizing XML Documents. Our work will be of great benefit, both to the research community and to the ICT industry. The project addresses one of the most important problems in XML usage and we expect our results to be published in important international forums, as has our preliminary research on the topic. This will significantly improve Australia's reputation in research in the ICT area. In the longer term, we intend to build commercial software tools based on the results of our research and this will be of direct benefit to the Australian economy and the Australian ICT industry.Read moreRead less
The impact of strategic alignment on IT outsourcing success in a complex service setting. Improved conceptual and methodological understanding of strategic alignment is essential for better IT outsourcing decisions. This research will improve the performance of Australian industry by investigating how strategically well aligned ITO investments can lead to improved performance and greater competitive advantage.
Improving Extensible Markup Language (XML) data quality using XML integrity constraints. The first benefit of the project will be the of development a new technology that will improve the data quality in Australian organizations using the rapidly growing Extensible Markup Language (XML) technology. It will also be of benefit to the Australian software industry, since the outcome of the project is a software tool for cleaning XML data that is aimed at eventual commercialisation in a quickly gro ....Improving Extensible Markup Language (XML) data quality using XML integrity constraints. The first benefit of the project will be the of development a new technology that will improve the data quality in Australian organizations using the rapidly growing Extensible Markup Language (XML) technology. It will also be of benefit to the Australian software industry, since the outcome of the project is a software tool for cleaning XML data that is aimed at eventual commercialisation in a quickly growing area of the software market. The project will also boost international research collaboration through the involvement of an overseas partner investigator, and expand Australia's expertise in the new area of XML technology through the training of a Ph.D. student.Read moreRead less