The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Inc ....Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Increasing our knowledge of the causes and consequences of adolescent drug abuse will improve Australia's ability to confront this problem and to develop early interventions and treatments that minimise associated harms.Read moreRead less
Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the dr ....Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the drug on young developing brains is particularly evident. The information gained in the current project will serve to inform medical and scientific communities, government policy makers, as well as the broader Australian community. Read moreRead less
Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepress ....Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepressant drugs and to the design of drugs to prevent the effects of cocaine.Read moreRead less
Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits with ....Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits within the school syllabus, is effective, and is scaleable to meet the needs of all schools in Australia. If it reduces the target risk factors by 10-20%, a minimal estimate based on the pilot work, then it will be a most cost effective contribution to promoting and maintaining the good health of the community.
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Pathways to positive personal and social adjustment in early adulthood: a follow-up of the Australian Temperament Project longitudinal cohort. Young adulthood today is characterised by delayed independence and family formation, extended attachment to peer culture, and relatively high levels of alcohol and drug use and mental health problems. Concerns are voiced about the capacity of this generation to become healthy and productive members of society. Examining the development of healthy young ad ....Pathways to positive personal and social adjustment in early adulthood: a follow-up of the Australian Temperament Project longitudinal cohort. Young adulthood today is characterised by delayed independence and family formation, extended attachment to peer culture, and relatively high levels of alcohol and drug use and mental health problems. Concerns are voiced about the capacity of this generation to become healthy and productive members of society. Examining the development of healthy young adulthood within this large longitudinal cohort will enable pathways and predictors of positive development from infancy through adolescence to be identified. It will hence allow identification of potential targets for policies and interventions to enhance the development of productive personal capacity, responsible social participation, compassion and trust.Read moreRead less