Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
Epilepsy is one of the most common chronic neurological disorders; it affects 1% of the world’s population, yet about 1 in 3 patients fail to achieve seizure control with current drugs. We will improve the properties of small molecules (drugs) that specifically target the GTPase activity of the enzyme dynamin, to reduce seizure effect in the brain by a novel mechanism. We will optimize and pre-clinically test these future chemical entities as potential anti-epileptic drugs.
Next-gen accident prevention: a new theory and toolkit for safer systems. This project aims to address limitations associated with existing accident causation theory and methodologies. Accident prevention across high risk industries is constrained by limitations in accident theory and methodologies. As a result, reductions in injuries and fatalities in most domains are plateauing. The expected outputs of the project include a new theory of accident causation, a new proactive risk assessment meth ....Next-gen accident prevention: a new theory and toolkit for safer systems. This project aims to address limitations associated with existing accident causation theory and methodologies. Accident prevention across high risk industries is constrained by limitations in accident theory and methodologies. As a result, reductions in injuries and fatalities in most domains are plateauing. The expected outputs of the project include a new theory of accident causation, a new proactive risk assessment methodology and a new methodology for analysing accidents. This will provide organisations and researchers with a powerful framework for enhanced accident analysis and prevention activities. This will provide significant benefits, associated with reductions in accidents, injuries and fatalities.Read moreRead less
Application of contemporary systems-based methods to reduce trauma at rail level crossings. Crashes at railway level crossings continue to cause significant trauma across Australia. Despite being a longstanding safety problem, the design and operation of level crossings has not changed considerably for decades. This research will provide an in-depth understanding of road user, environmental and infrastructure-related factors that influence safety and performance at rail level crossings. This wil ....Application of contemporary systems-based methods to reduce trauma at rail level crossings. Crashes at railway level crossings continue to cause significant trauma across Australia. Despite being a longstanding safety problem, the design and operation of level crossings has not changed considerably for decades. This research will provide an in-depth understanding of road user, environmental and infrastructure-related factors that influence safety and performance at rail level crossings. This will be used to develop a world-first model of the level crossing system that is needed to support the development of innovative countermeasures that will improve safety. Reductions in the levels of significant trauma at level crossings, and new public policy for level crossing upgrades, are the intended real-world outcomes.Read moreRead less
Dynamic Rollover Occupant Protection (DROP): evaluation and regulation. This projects seeks to establish which occupant crashworthiness attributes a vehicle must possess to prevent injury in a rollover crash. The results will assist regulators, industry and consumer groups understand which critical factors need to be considered to develop rollover crashworthiness regulations, consumer tests and vehicle purchase policy.
Discovery Early Career Researcher Award - Grant ID: DE180100825
Funder
Australian Research Council
Funding Amount
$336,128.00
Summary
Evaluating interventions to prevent serious road traffic crashes. This project aims to advance knowledge on the prevention of road traffic crashes that result in serious injury or death. Road traffic injuries are the second leading cause of hospitalised injury and injury-related deaths in Australia, and are estimated to cost the economy $27 billion annually. This project will establish a data collection system that will evaluate existing and novel countermeasures to serious road traffic crashes. ....Evaluating interventions to prevent serious road traffic crashes. This project aims to advance knowledge on the prevention of road traffic crashes that result in serious injury or death. Road traffic injuries are the second leading cause of hospitalised injury and injury-related deaths in Australia, and are estimated to cost the economy $27 billion annually. This project will establish a data collection system that will evaluate existing and novel countermeasures to serious road traffic crashes. The outcome of this project will inform road safety policies and cost-effective countermeasures. Insights from the project can contribute to road safety improvements in Australia and a substantial reduction in the burden of fatal and non-fatal road traffic injury.Read moreRead less
Innovative and human-centred design in underground coalmining: a new concept vehicle for safe personnel transport. Australian coalminers commute daily on a system of underground roads to the ‘longwall’, the site where their work can begin, in vehicles that are primitive by aboveground standards. These current vehicles contribute to short- and long-term injuries amongst mining personnel. This project will develop benchmark standards for an innovative underground personnel carrier that promotes a ....Innovative and human-centred design in underground coalmining: a new concept vehicle for safe personnel transport. Australian coalminers commute daily on a system of underground roads to the ‘longwall’, the site where their work can begin, in vehicles that are primitive by aboveground standards. These current vehicles contribute to short- and long-term injuries amongst mining personnel. This project will develop benchmark standards for an innovative underground personnel carrier that promotes a safer and healthier working environment by contributing to reduced injury rates and ensuring the comfort of workers. This project contributes to the health and welfare of coalminers in regional Australia and in the international mining sector through innovative and ’human-centred’ design.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100025
Funder
Australian Research Council
Funding Amount
$2,259,000.00
Summary
ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased a ....ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased access to growing export markets. Intended benefits to industry are ready-to-use technologies for strengthened food safety, and a new generation of highly-skilled food safety scientists with experience in conducting industry-focused research.Read moreRead less