Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining lif ....Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining life of the building. The only related research involves reinforced concrete which suggests that a reduction of at least 33 per cent could be expected. Hence, this project will quantify the long-term strength of FRP reinforced brickwork to enable engineers to safely apply this new cost-effective retrofit technique.Read moreRead less
Composite tubular construction subject to impact and blast loading. This project will advance the knowledge of composite tubular members and connections under impact and blast loading. It will provide confident design methodology against impact and blast loading for buildings designated as prominent targets or items of critical infrastructure, to save lives and reduce losses.
Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to b ....Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to be considered for each design decision. This will greatly reduce rework and poor design decisions based on missed information. It will also ensure that participants are aware of all related information for their particular design tasks.Read moreRead less
Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, lead ....Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, leading to damage. This project aims to study the internal pressures generated in buildings with a range of volumes and openings in the envelope. A combination of model-scale and full-scale tests and theoretical analysis are planned to determine critical parameters for highly turbulent air-flow though openings. Results will inform the revision of design data in codes and of guidelines for consistent, optimal design of buildings.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100138
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems ....National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems. The facility may advance understanding of the fundamental behaviour of critical infrastructure exposed to impact loading and will foster innovations in design and construction. Applications may include improvement of the structural safety of infrastructure including railway networks, tunnels and bridges, and also the development of cost-effective and environmentally friendly building and construction materials. Read moreRead less
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.