Neuropathic pain is particularly difficult to treat and existing medications have considerable side effects. This project will develop a new set of glycine transport inhibitors that have the potential to provide pain relief without side effects.
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100113
Funder
Australian Research Council
Funding Amount
$420,437.00
Summary
Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of ....Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of modular interconnections and their integration strategies, this project expects to enhance the industry’s capacity to adopt safe, economical and standardised designs of modular systems. This project should significantly reduce the risk in decision making in modular construction, and transformation to advanced building manufacturing technologies in Australia and beyond.Read moreRead less
Surfacing urban wetlands in two urban renewal sites in Sydney. Urban wetlands in Australia provide benefits for climate change mitigation, pollution reduction, habitat provision and socioecological connection. However, in large cities like Sydney, urban wetlands are unseen because undergrounded, and, therefore not adequately understood. This illegibility, and loss of understanding by residents, planners and policy makers impedes wetlands' good management. This project surfaces wetlands through v ....Surfacing urban wetlands in two urban renewal sites in Sydney. Urban wetlands in Australia provide benefits for climate change mitigation, pollution reduction, habitat provision and socioecological connection. However, in large cities like Sydney, urban wetlands are unseen because undergrounded, and, therefore not adequately understood. This illegibility, and loss of understanding by residents, planners and policy makers impedes wetlands' good management. This project surfaces wetlands through visualisation in a multimodal knowledge platform focusing on two urban renewal sites, Green Square and Marrickville South. We leverage design ethnography to develop resources for strengthening multiple stakeholders’ socioecological engagement through methods empowering just, creative and open participation.Read moreRead less
Using acoustic retroreflection in architecture to improve rooms for speech. This project aims to discover how a novel form of acoustic treatment can improve acoustics for speech in rooms such as classrooms and open-plan offices. The project will generate new knowledge on the theory, design, and effects of acoustically retroreflective surfaces in room acoustics. Expected outcomes include solutions for effective acoustic retroreflectors, knowledge on how retroreflection influences people’s voice r ....Using acoustic retroreflection in architecture to improve rooms for speech. This project aims to discover how a novel form of acoustic treatment can improve acoustics for speech in rooms such as classrooms and open-plan offices. The project will generate new knowledge on the theory, design, and effects of acoustically retroreflective surfaces in room acoustics. Expected outcomes include solutions for effective acoustic retroreflectors, knowledge on how retroreflection influences people’s voice regulation and sound quality perception, and guidelines and simulation tools for integrating retroreflective treatments to improve speaking comfort. This should provide significant benefits including opportunities to resolve seemingly intractable design dilemmas in the acoustics of education and workplace environments.Read moreRead less
Place and parametricism: Provocations for the rethinking of design. This project aims to explore whether quantitative methods of digital and parametric design can adequately encompass place. Quantitative digital and parametric approaches increasingly dominate contemporary architecture, but people assume architectural design should be essentially oriented to questions of place. The project will operate through a set of studio provocations based on the fictional places of Mervyn Peake's Gormenghas ....Place and parametricism: Provocations for the rethinking of design. This project aims to explore whether quantitative methods of digital and parametric design can adequately encompass place. Quantitative digital and parametric approaches increasingly dominate contemporary architecture, but people assume architectural design should be essentially oriented to questions of place. The project will operate through a set of studio provocations based on the fictional places of Mervyn Peake's Gormenghast novels. The project is expected to clarify the nature of place and parametricism, and rethink what design itself might be.Read moreRead less
Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structu ....Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structural design of built-up sections through experimental and theoretical research, studying the new failure modes pertaining to built-up sections, the increase in strength achievable from composite action and the optimum arrangement of fasteners. Read moreRead less
Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remot ....Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remote housing. The project aims to design and test an integrated low impact or autonomous transportable house. The results of this research are applicable to remote defence sites, small rural townships and Aboriginal communities as well as for international export.Read moreRead less
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.