Neuropathic pain is particularly difficult to treat and existing medications have considerable side effects. This project will develop a new set of glycine transport inhibitors that have the potential to provide pain relief without side effects.
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structu ....Built-up cold-formed steel structures. The building industry is seeing a rapid uptake of joining two or more cold-formed steel sections to form large built-up sections with high carrying capacities. The joining consists of screws, or similar fasteners, placed intermittently along the member. The ease of joining encourages innovation in forming versatile new built-up section shapes in expanding areas of application. The project will provide guidelines and numerical tools for the efficient structural design of built-up sections through experimental and theoretical research, studying the new failure modes pertaining to built-up sections, the increase in strength achievable from composite action and the optimum arrangement of fasteners. Read moreRead less
Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remot ....Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remote housing. The project aims to design and test an integrated low impact or autonomous transportable house. The results of this research are applicable to remote defence sites, small rural townships and Aboriginal communities as well as for international export.Read moreRead less
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Shallow foundations in unsaturated soils: mechanistic design through numerical modelling, analysis and experimental investigation. This project will close the knowledge gap of how shallow foundations perform in variably saturated soils. It will integrate expertise in unsaturated soil mechanics, theory of elasto-plasticity, numerical modelling, limit analysis and experimental investigation. It will achieve a rigorous understanding of footings founded on unsaturated soils subjected to monotonic lo ....Shallow foundations in unsaturated soils: mechanistic design through numerical modelling, analysis and experimental investigation. This project will close the knowledge gap of how shallow foundations perform in variably saturated soils. It will integrate expertise in unsaturated soil mechanics, theory of elasto-plasticity, numerical modelling, limit analysis and experimental investigation. It will achieve a rigorous understanding of footings founded on unsaturated soils subjected to monotonic loading using a recently developed experimental testing facility, and analyses using finite elements, the method of characteristics and zero extension line theory. Impact and adoption in industry will be direct through world first design tools which incorporate the influence of suction on bearing capacity, settlement and safety.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100779
Funder
Australian Research Council
Funding Amount
$396,935.00
Summary
Co-design using participatory urban media. This project aims to use participatory urban media to test the effectiveness of co-designed screen-based interfaces in helping government and urban planners to better understand and design for rapidly urbanising cities by engaging designers and city stakeholders. Using Chongqing in China as a case study, it intends to generate new knowledge about the value of participatory urban media installations as transformative interventions in traditional urban de ....Co-design using participatory urban media. This project aims to use participatory urban media to test the effectiveness of co-designed screen-based interfaces in helping government and urban planners to better understand and design for rapidly urbanising cities by engaging designers and city stakeholders. Using Chongqing in China as a case study, it intends to generate new knowledge about the value of participatory urban media installations as transformative interventions in traditional urban design. Expected outcomes include a reproducible approach to co-designing urban media for participatory engagement between city stakeholders and citizens which should significantly increase the capacity of Australia-China design partnerships to manage pressing regional urban and placemaking problems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100130
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure ....An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure and the ground under such loading. The shaking table will simulate earthquakes and enable controlled testing of three-tonne models of foundation and soil-structure interaction systems typical of Australia's infrastructure. The discoveries made are expected to be integral to the modernisation of Australia's seismic design standards so that earthquake-induced damage and risk exposure can be minimised.Read moreRead less
Behaviour of ultra-high strength double-skin composite tubular construction. Ultra-high strength (UHS) steel tubes are currently used mainly in the vehicle industry due to their high strength and light weight. This project aims to enable the building of more resilient and sustainable infrastructure by utilising these UHS steel tubes in double-skin composite tubular construction. To date there has been little work to understand the effects of fire, earthquake and impact related incidents on these ....Behaviour of ultra-high strength double-skin composite tubular construction. Ultra-high strength (UHS) steel tubes are currently used mainly in the vehicle industry due to their high strength and light weight. This project aims to enable the building of more resilient and sustainable infrastructure by utilising these UHS steel tubes in double-skin composite tubular construction. To date there has been little work to understand the effects of fire, earthquake and impact related incidents on these structures. This project aims to access unique testing facilities for full size impact and fire testing and the state-of-the-art hybrid testing simulation. It is expected to increase the competitiveness of the Australian manufacturing industry by overcoming the bottleneck in the manufacture of steel sections.Read moreRead less