Understanding The Methamphetamine Epidemic And Its Implications For Service Provision And Harm Reduction: The VicMeth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,270,774.00
Summary
The Victorian methamphetamine epidemic has received extensive media coverage highlighting the devastating impact of the drug and resultant public concern. We will follow up a cohort of 800 methamphetamine smokers from metropolitan and regional Victoria bi-annually for a period of 5 years to determine the natural history of methamphetamine use to inform optimal intervention strategies and arrest the increases in harm observed in Victoria recently.
Prof Hall is a population health researcher investigating the public health and public policy implications of neurobiological and genetic research on alcohol and other drug use and addiction. My research includes: the social and health system implications of new pharmacological treatments for addiction arising from neurobiological and genetic research; new approaches suggested for the prevention of drug use and addiction (for example, genetic screening and vaccination); and the impact of neurobi ....Prof Hall is a population health researcher investigating the public health and public policy implications of neurobiological and genetic research on alcohol and other drug use and addiction. My research includes: the social and health system implications of new pharmacological treatments for addiction arising from neurobiological and genetic research; new approaches suggested for the prevention of drug use and addiction (for example, genetic screening and vaccination); and the impact of neurobiological and genetic research findings on public understanding of, attitudes towards, and support for, different social policies that aim to deal with drug use and addiction.Read moreRead less
Cannabis is the most widely used illicit drug in the world. Delta-9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, is known to be preferentially taken up into fat tissue where it can be stored for weeks, months and possibly years. Boy fat has the capacity to store large quantities of THC and the slow passive release of THC from fat cells into the blood accounts for why THC remains at detectable levels in the blood or urine for weeks after exposure to cannabis. Under n ....Cannabis is the most widely used illicit drug in the world. Delta-9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, is known to be preferentially taken up into fat tissue where it can be stored for weeks, months and possibly years. Boy fat has the capacity to store large quantities of THC and the slow passive release of THC from fat cells into the blood accounts for why THC remains at detectable levels in the blood or urine for weeks after exposure to cannabis. Under normal conditions the slow passive release of THC from fat cells has negligible effects on the user as the amounts involved are so small. However, we have recent preliminary evidence to show that conditions associated with increased fat metabolism (e.g. dieting, exercise or stress) cause a greatly enhanced release of THC from fat stores into the blood supply. Further, we have demonstrated that such levels attained promote significant behavioural and physiological changes The current proposal aims to further characterise this phenomenon. We aim to: (1) determine the length of time that THC can be stored in fat before being released into blood, (2) establish that the release of THC stored in fat tissue may be promoted by fat breakdown associated with food deprivation, stress or exercise, (3) characterise the physiological and behavioural effects of THC released from fat, (4) determine the mechanisms responsible for THC release from fat, and (5) determine if THC released from fat can cross from the bloodstream into saliva. This proposal has far reaching consequences for our understanding of the long-term effects on cannabis use on physical health and behaviour. Further, it may have major implications for the correct interpretation of analytical data from road-side saliva testing and forensic and criminal cases involving cannabis use.Read moreRead less
Alcohol,tobacco, Illicit And Prescribed Drugs: Prospective Cohorts And RCTs
Funder
National Health and Medical Research Council
Funding Amount
$714,745.00
Summary
This research addresses the important areas of infant, childhood, adolescent, adult, and family well-being and the effects of exposure to tobacco, alcohol, and illicit drug use. The impacts of these substances on psychological, cognitive, vocational, and physical well-being remain poorly researched. A related set of research projects is aimed to build the evidence base for effective intervention to prevent or manage psychological and cognitive sequelae from such exposure.
The Investigation Of Markers Of Relapse And Potential Therapeutic Targets In Methamphetamine Dependence Using Novel Techniques
Funder
National Health and Medical Research Council
Funding Amount
$103,088.00
Summary
This project focuses on methamphetamine dependence. It will investigate some of the major harms associated with methamphetamine use and will seek to identify who is more likely to develop these harms. This research will use a range of novel measures and techniques to investigate biological, psychological, cognitive and social risk factors for methamphetamine-related harms. This study will contribute to a better understanding of methamphetamine dependence, and potential targets for treatment.
Brain Pathways Underlying Vulnerability To Drug Relapse
Funder
National Health and Medical Research Council
Funding Amount
$416,788.00
Summary
Addiction to drugs is a major health and social burden for Australian society. Once addiction is established, prevention of relapse is the most significant obstacle to successful treatment. Unfortunately, efficacious pharmaceutical options to treat relapse are lacking. By employing an animal model of relapse that accurately reflects drug taking in humans the proposed project aims to advance our understanding of the brain mechanism underlying addiction.
Understanding Australia’s Drug Use: Prescription Psychotropics, Recreational Drugs And Novel Emerging Psychoactive Substances
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
Australians are consuming record levels of drugs that affect their mood and behaviour, both prescribed and illicit. They are also consuming an increasing array of novel synthetic drugs, the effects of which are largely unknown. Professor Iain McGregor engages in innovative research that examines the drugs we take, their effects on the brain, and their risks and benefits. His team also develops new medications that may become future treatments for anxiety, depression and addictions.
Evaluating The Effectiveness Of Future Tobacco Control Strategies
Funder
National Health and Medical Research Council
Funding Amount
$368,112.00
Summary
This research will evaluate promising new strategies to reduce the harm caused by tobacco, the leading preventable cause of premature death in Australia. This includes evaluation of general population-based strategies, such as public smoking bans, and interventions to help smokers quit smoking, such as new cessation aids and long-term maintenance on pharmaceutical nicotine or low-nitrosamine smokeless tobacco.
Brain Circuits Promoting Abstinence And Preventing Relapse To Alcohol Seeking
Funder
National Health and Medical Research Council
Funding Amount
$591,995.00
Summary
This project maps and manipulates the brain circuits that promote abstinence from alcohol use. It uses new techniques from neuroscience to control the activity of specific cell types in discrete brain circuits. In this way we can alter the activity of these circuits to build on the normal neural restorative processes that occur during abstinence from alcohol use to reduce, and possibly prevent, relapse.