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Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes th ....Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes that regulate flowering and seed production in sorghum in response to changes in temperature and light interactions. These studies will help to develop novel sorghum varieties with desirable characters through plant-breeding programmes.Read moreRead less
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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Dark Matter Discovery. Dark matter research is fundamental breakthrough science, thus its National and Community benefits can only be indirect. This, nevertheless, does not reduce the importance of these benefits. The proposed program strengthens Australian fundamental science by extending it in a new direction, and considerably boosts the quality of theoretical dark matter research in Australia. Since a large part of the proposed work is expected to be performed in international collaboratio ....Dark Matter Discovery. Dark matter research is fundamental breakthrough science, thus its National and Community benefits can only be indirect. This, nevertheless, does not reduce the importance of these benefits. The proposed program strengthens Australian fundamental science by extending it in a new direction, and considerably boosts the quality of theoretical dark matter research in Australia. Since a large part of the proposed work is expected to be performed in international collaboration, positive results will increase the Australian presence on the international astro-particle physics scene. Successful students involved in this project are also expected to assume leading roles in international dark matter research.Read moreRead less
Origins of our Universe. The present proposal will study the origins of our Universe, which is one of the grand challenges of 21st century physics. As such it will utilise insights and discoveries in many areas of physics, ranging from string theory and particle physics at the highest energies, to x-ray, optical and radio astronomy. The research program will add to our understanding of a fundamental branch of science - extending it in new directions - thereby considerably boosting the quality of ....Origins of our Universe. The present proposal will study the origins of our Universe, which is one of the grand challenges of 21st century physics. As such it will utilise insights and discoveries in many areas of physics, ranging from string theory and particle physics at the highest energies, to x-ray, optical and radio astronomy. The research program will add to our understanding of a fundamental branch of science - extending it in new directions - thereby considerably boosting the quality of cosmology and theoretical physics research in Australia. In concert with our international collaborations, work arising from this fellowship will enhance the Australian presence on the international cosmology, astro-particle, and theoretical physics scene.
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Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will im ....Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will improve our mechanistic understanding of genetic diseases in populations. In addition, this proposal is expected to lead to identification of potential targets and technologies that would be of interest to Australian industry.Read moreRead less
Re-balancing global resources: Manipulating toxic prussic acid (dhurrin) to improve nitrogen use efficiency in forage sorghum in a changing climate. Sorghum is grown widely is Australia and world-wide for forage, grain (mostly for animal feed) and biofuels. It grows well in dry areas. The problem is that the leaves contain a toxin that releases prussic acid (cyanide) that can reduce animal production or even kill stock feeding on it, especially when water stressed. The problem will get worse wit ....Re-balancing global resources: Manipulating toxic prussic acid (dhurrin) to improve nitrogen use efficiency in forage sorghum in a changing climate. Sorghum is grown widely is Australia and world-wide for forage, grain (mostly for animal feed) and biofuels. It grows well in dry areas. The problem is that the leaves contain a toxin that releases prussic acid (cyanide) that can reduce animal production or even kill stock feeding on it, especially when water stressed. The problem will get worse with climate change. Low-cyanide plants developed by us using non-GM methods grow fast, but accumulate nitrate instead which is also toxic. This is a waste of expensive fertiliser too. We aim to develop plants that divert resources to growth instead of toxins in order to reduce fertiliser use and help prepare for the future. The fast growing plants may also be useful as a biofuel crop.Read moreRead less