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Molecular And Structural Determinants Of Myocardial Dysfunction And Prognosis In Left And Right Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The aim of this research is to investigate the role of inherited genetic variation on myocardial function and prognosis in patients with cardiomyopathies as well as pulmonary hypertension. Clinical, cardiac genomic and myocardial tissue studies will be undertaken in various patient cohorts. It is hoped that this research will provide new insights into disease mechanisms, and will contribute to new approaches to patient management and risk stratification.
An Integrated “omic” Approach To Neurodevelopmental Disorders Using Disease-discordant Monozygotic Twins
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
This project targets neurodevelopment disorders such as autism spectrum disorder, cerebral palsy and epilepsy and focuses on studying the environmental factors (epigenetics) affecting the disease mechanisms in these disorders. The study will be performed on twin samples and will help in the diagnosis of the disease risk at an earlier stage. It will also help to understand the causes of these important neurological diseases.
Peritoneal Metastases From Colorectal Carcinoma: Exploring The Potential Of Immunotherapy As A Treatment Adjunct
Funder
National Health and Medical Research Council
Funding Amount
$89,197.00
Summary
Twenty percent of patients with bowel cancer have disease involving the lining of the abdomen, called the peritoneum. These patients do poorly. The majority are inoperable, and chemotherapy has poor response in these patients. Therefore, there is a dire need to explore new treatments. Newer drugs that stimulate the immune cells to fight cancer have shown promise in other cancers. We aim to assess the potential of this treatment in peritoneal disease, with the aim of improving patient outcomes.
Clinical Genetics Studies Of Speech And Language Disorders In Large Families.
Funder
National Health and Medical Research Council
Funding Amount
$160,368.00
Summary
Childhood speech and language disorders are common and may have negative long term outcomes. We have a limited understanding of what causes these disorders, which impacts our ability to manage and treat those affected. This project will utilise large families to investigate causes and clinical features of speech and language disorders. This is an exciting and relatively under-research area, and has the potential to lead to improved outcomes for children affected with speech and language disorder ....Childhood speech and language disorders are common and may have negative long term outcomes. We have a limited understanding of what causes these disorders, which impacts our ability to manage and treat those affected. This project will utilise large families to investigate causes and clinical features of speech and language disorders. This is an exciting and relatively under-research area, and has the potential to lead to improved outcomes for children affected with speech and language disorder.Read moreRead less
Impact Of Cognitive Training On Improving Emotional And Cognitive Function: Testing Predictors And Moderators Of Treatment Response In Twins.
Funder
National Health and Medical Research Council
Funding Amount
$97,419.00
Summary
This project evaluates the effectiveness of a web-based cognitive training tool, MyBrainSolutions, in improving emotional and cognitive function over acute (30 days) and long-term periods (1-year). The impact of the cognitive training on both trained and untrained real-world functions will be investigated, as well as the minimum time commitment required to see improvement. By comparing identical to non-identical twins, a comparison of the relative impact of genetics versus environment in improvi ....This project evaluates the effectiveness of a web-based cognitive training tool, MyBrainSolutions, in improving emotional and cognitive function over acute (30 days) and long-term periods (1-year). The impact of the cognitive training on both trained and untrained real-world functions will be investigated, as well as the minimum time commitment required to see improvement. By comparing identical to non-identical twins, a comparison of the relative impact of genetics versus environment in improving scores can be evaluated.Read moreRead less
Host Cell Signalling During HTLV-1 Infection: Novel Insights And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$62,335.00
Summary
Human T-leukemia virus 1 (HTLV-1) establishes a life-long infection and causes cancer and immune dysfunction. This study aims to find a cure for HTLV-1 by inducing the specific death of infected cells using novel therapeutic drugs that target host cell death pathways. Dead infected cells are then naturally cleared from the system along with the viral infection. The impact of HTLV-1 infection on tuberculosis severity will also be examined.
Exploring The Immune Landscape Of Anal Squamous Cell Carcinoma And The Therapeutic Utility Of Immunotherapies
Funder
National Health and Medical Research Council
Funding Amount
$48,791.00
Summary
Anal cancer has been on the rise without improvements in patient treatment or survival over the last three decades. Immunotherapy which uses a patient's immune system to combat cancer has demonstrated great success in the treatment of several tumours, and consequently demands investigation for patients with anal cancer. This project is focussed on examining the immune system's role in anal cancer, and whether immunotherapies can be used to improved treatment response and patient survival.
Improving Health Services Around The Time Of Childbirth In Places Where Death Rates Are High And Home-births Common
Funder
National Health and Medical Research Council
Funding Amount
$119,335.00
Summary
In settings close to Australia where death rates among mothers and newborns remain high, it is common for childbirth to take place outside of health facilities. This research will develop feasible options for countries aiming to simultaneously improve care in first-line health facilities (which often takes some years), and simultaneously provide some limited services in the home that can reduce deaths immediately.
Understanding Current And Future Opportunities To Promote Healthy Maternal Weight During Pregnancy And The Postpartum Period
Funder
National Health and Medical Research Council
Funding Amount
$75,620.00
Summary
The PhD will document clinical management of maternal weight gain during and post pregnancy, across a range of antenatal care providers and deliver a nine month pilot intervention study for first time mothers, aimed at reducing post pregnancy weight retention and promoting healthy nutrition and physical activity behaviours. Findings from this PhD will inform important future development of healthy weight interventions across the reproductive years.
The Impact Of Infections, Anaemia, And Micronutrient Deficiencies On Infant Birth Weight And Growth
Funder
National Health and Medical Research Council
Funding Amount
$83,613.00
Summary
This research aims to determine the impact of infectious diseases, anemia and nutritional deficiencies on low birth weight and infant growth in rural Papua New Guinea. The health of pregnant women and their babies will be assessed during pregnancy and up to 12 months post birth. We will determine which health indicators cause low birth weight and poor infant growth to enable development of interventions to improve health and pregnancy outcomes.