Discovery Early Career Researcher Award - Grant ID: DE120100049
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
New integer programming based theory, formulations and decomposition techniques with applications to integrated problems. Optimisation problems permeate science and industry. By developing new techniques to solve larger and harder problems than is currently possible, more complex questions can be answered, and more accurate solutions obtained. Industries can use such tools to make better financial, resource management, operational, and/or strategic planning decisions.
Discovery Early Career Researcher Award - Grant ID: DE170100234
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Exact and hybrid algorithms for the Aircraft Landing Problem. This project aims to develop algorithms with superior guaranteed performance. Aircraft Landing Problems (ALP) are an important class of decision problems. Optimal solution of an ALP is applicable in transportation and health care delivery, benefitting systems experiencing long delays. This project aims to address several of the Australian Government's Science and Research Priorities, focusing on food supply chains, effective operation ....Exact and hybrid algorithms for the Aircraft Landing Problem. This project aims to develop algorithms with superior guaranteed performance. Aircraft Landing Problems (ALP) are an important class of decision problems. Optimal solution of an ALP is applicable in transportation and health care delivery, benefitting systems experiencing long delays. This project aims to address several of the Australian Government's Science and Research Priorities, focusing on food supply chains, effective operation and resource allocation in transport, and better models of health care delivery and services.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100110
Funder
Australian Research Council
Funding Amount
$3,021,288.00
Summary
New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight i ....New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight into fundamental biomedical processes. In this way, the project expects to affect a paradigm shift in mathematical biology while strengthening Australia’s reputation as a world-leader in mathematical biology. An outcome from this project could be new mathematical models that guide decision making in the clinic.Read moreRead less
Mathematical measurement and modelling of neuronal degeneration. Currently about 150,000 Australian's suffer from cognitive impairment due to Alzheimer's disease or dementia and this number is expected to double over the next few decades. By combining newly developed mathematical methods in complex systems with sophisticated neural imaging we will develop new techniques to advance the diagnosis and treatment of cognitive decline in normal ageing and neurodegenerative disease.
This project will ....Mathematical measurement and modelling of neuronal degeneration. Currently about 150,000 Australian's suffer from cognitive impairment due to Alzheimer's disease or dementia and this number is expected to double over the next few decades. By combining newly developed mathematical methods in complex systems with sophisticated neural imaging we will develop new techniques to advance the diagnosis and treatment of cognitive decline in normal ageing and neurodegenerative disease.
This project will also maintain the collaborative link between researchers in Biomathematics at Mount Sinai School of Medicine, New York and researchers in Applied Mathematics at UNSW that enables training of Australian scientists in the vital area of mathematical bio-complexity.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Mathematical models and bioinformatic analyses of bacterial genome evolution. Bacteria are vital agents in earth's biosphere, breaking down and synthesising a wide variety of compounds. Some bacteria cause disease; others are exploited for a range of biotechnological applications. Bacteria have a remarkable ability to survive and thrive in changing conditions. For example, pathogenic bacteria confronted by antibiotics easily evolve resistance to them. With the reality of climate change, we expec ....Mathematical models and bioinformatic analyses of bacterial genome evolution. Bacteria are vital agents in earth's biosphere, breaking down and synthesising a wide variety of compounds. Some bacteria cause disease; others are exploited for a range of biotechnological applications. Bacteria have a remarkable ability to survive and thrive in changing conditions. For example, pathogenic bacteria confronted by antibiotics easily evolve resistance to them. With the reality of climate change, we expect more rapid shifts in the structure of bacterial communities, possibly leading to the emergence of new pathogens. The benefits of this project are to discover how the genetic structure of bacteria confer this flexibility, and to help keep Australia at the forefront of research in bioinformatics and mathematical biology.
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Multiscale modelling: Applications to the Biomedical Sciences. 1) Significant reductions in the costs of developing pharmaceutical treatments, 2) Substantial reduction in hospitalisation costs, 3) Improved treatment of wounds, a significant cause of chronic ill-health which presently costs the Australian HealthCare System A$500,000,000/year.
Mathematical modelling can provide vital information on the effectiveness and practical implementation of microbicides and vaccines against HIV. This project will produce mathematical models of the earliest stages of HIV infection suitable for investigation of the implementation of vaccines and microbicides. It will provide a framework to investigate why these interventions have performed poorly to date, and how these may be better implemented.
Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.
Allocating scarce HIV/AIDS antiretroviral drugs in resource-constrained countries: using modelling to develop tools and analyse consequences of ethics and HIV-epidemiology. This project will benefit communities in some of the poorest countries of the world, suffering greatly from the HIV/AIDS epidemic. This research is important and timely for these nations in deciding how to distribute the limited treatment in an ethical manner to address treatment principles of these countries. However, the me ....Allocating scarce HIV/AIDS antiretroviral drugs in resource-constrained countries: using modelling to develop tools and analyse consequences of ethics and HIV-epidemiology. This project will benefit communities in some of the poorest countries of the world, suffering greatly from the HIV/AIDS epidemic. This research is important and timely for these nations in deciding how to distribute the limited treatment in an ethical manner to address treatment principles of these countries. However, the methods developed can also be applied to other diseases in different regions and people, such as Australian aborigines to increase their quality of health. Specifically, an epidemic of Chlamydia is widespread amongst the aboriginal communities of Australia's Northern Territory. Tools developed in this project will be easily adaptable to address control measures for Chlamydia among this population. Read moreRead less