Analysis of the structure of latin squares. The benefits to Australia of fundamental research in core disciplines such as mathematics are well documented. Discrete mathematics and combinatorics are boom disciplines of the computer age and this project seeks new knowledge concerning basic building blocks of combinatorial mathematics. The outcomes will be of interest to theoretical discrete mathematicians around the world, enhancing Australia's already high research profile in this important area ....Analysis of the structure of latin squares. The benefits to Australia of fundamental research in core disciplines such as mathematics are well documented. Discrete mathematics and combinatorics are boom disciplines of the computer age and this project seeks new knowledge concerning basic building blocks of combinatorial mathematics. The outcomes will be of interest to theoretical discrete mathematicians around the world, enhancing Australia's already high research profile in this important area of pure mathematical research. Importantly, the problems under investigation offer substantial opportunity for excellent postgraduate training, critical for the future of Australian research. Read moreRead less
Random Structures and Asymptotics. Discrete random structures have many uses in algorithms in computer science (for instance, random networks modelling computer link-ups), biology (for instance, random sequences modelling DNA) and engineering. New techniques for studying these structures will lead to powerful new results on their properties. The emphasis will be on the behaviour of the random structures when their size becomes large. With the advent of
more powerful computing techniques, it is ....Random Structures and Asymptotics. Discrete random structures have many uses in algorithms in computer science (for instance, random networks modelling computer link-ups), biology (for instance, random sequences modelling DNA) and engineering. New techniques for studying these structures will lead to powerful new results on their properties. The emphasis will be on the behaviour of the random structures when their size becomes large. With the advent of
more powerful computing techniques, it is often the large-scale behaviour which has relevance to the more diffucult computations being undertaken. The results are also of potential application to other areas of mathematics.Read moreRead less
Interconnection Network Routing and Graph Symmetry. Efficient routing schemes are of fundamental importance to both
traditional and optical interconnection networks. To achieve high
performance it is recommended that the graph modelling the network be vertex-transitive, meaning that it looks the same viewed from any vertex. In this project we will conduct a systematic study of the routing problem for such networks. We will focus on the effect of vertex-transitivity and some other symmetry pro ....Interconnection Network Routing and Graph Symmetry. Efficient routing schemes are of fundamental importance to both
traditional and optical interconnection networks. To achieve high
performance it is recommended that the graph modelling the network be vertex-transitive, meaning that it looks the same viewed from any vertex. In this project we will conduct a systematic study of the routing problem for such networks. We will focus on the effect of vertex-transitivity and some other symmetry properties on the efficiency of routing schemes measured by the vertex- and edge-congestions, and the minimum number of wavelengths needed in optical networks.Read moreRead less
Improving Upper and Lower Bounds on the Order of Large Graphs under Degree and Distance Constraints. Networks govern all aspects of society, including transportation networks, communication networks, computer networks and networks for the distribution of goods etc. - and the theoretical analysis of such networks has become a subject of fundamental importance. Networks can be modelled by graphs. This project will provide new theoretical results which will improve our knowledge of network topologi ....Improving Upper and Lower Bounds on the Order of Large Graphs under Degree and Distance Constraints. Networks govern all aspects of society, including transportation networks, communication networks, computer networks and networks for the distribution of goods etc. - and the theoretical analysis of such networks has become a subject of fundamental importance. Networks can be modelled by graphs. This project will provide new theoretical results which will improve our knowledge of network topologies. The new knowledge will then be utilised in the construction of large graphs with respect to given maximum degree and distance constraints.Read moreRead less
Information security and digital watermarking with Latin squares. The importance of digital information is increasing constantly. Audio, video, and still image data dominate our daily lives. Such information has commercial and strategic importance. It is invaluable in crime prevention: for example, video from security cameras. The protection of commercially valuable material against piracy and sensitive information against security breaches is vital to our economy and our safety. This project ad ....Information security and digital watermarking with Latin squares. The importance of digital information is increasing constantly. Audio, video, and still image data dominate our daily lives. Such information has commercial and strategic importance. It is invaluable in crime prevention: for example, video from security cameras. The protection of commercially valuable material against piracy and sensitive information against security breaches is vital to our economy and our safety. This project addresses these issues, by developing new, secure watermarks and fingerprints to protect digital information. Such watermarks can also protect radio communication channels, which is important due to the rising demand for wireless connectivity.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Mathematical modelling in developmental biology. Modern observational techniques in biology and medicine generate a wealth of genetic and molecular detail. Mathematical modelling integrates and synthesises this information to provide insight into how complex biological processes are coupled to produce experimentally observed behaviour. Mathematical modelling generates experimentally testable predictions that can be used to verify the validity of the models. This program is dedicated to exciting ....Mathematical modelling in developmental biology. Modern observational techniques in biology and medicine generate a wealth of genetic and molecular detail. Mathematical modelling integrates and synthesises this information to provide insight into how complex biological processes are coupled to produce experimentally observed behaviour. Mathematical modelling generates experimentally testable predictions that can be used to verify the validity of the models. This program is dedicated to exciting opportunities for advancing our knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes will lead to prediction and treatment of congenital disorders and contribute to a healthy start to life. Read moreRead less
Geometry of manifolds of non-negative scalar curvature. This proposal will benefit Australia in several ways: Its outcomes will make Australia a world leader in research on scalar curvature, and consequently help Australia secure its position among world leaders in research on differential geometry and differential equations; Overseas world-class experts will be attracted to Australia by the impact of this research to develop further collaboration; More and more talented Australian students will ....Geometry of manifolds of non-negative scalar curvature. This proposal will benefit Australia in several ways: Its outcomes will make Australia a world leader in research on scalar curvature, and consequently help Australia secure its position among world leaders in research on differential geometry and differential equations; Overseas world-class experts will be attracted to Australia by the impact of this research to develop further collaboration; More and more talented Australian students will be motivated to pursue science-based and mathematics based studies, thereby improving the mathematical skills of the Australian workforce.Read moreRead less
Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identi ....Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identifying RNA molecules that contribute to quantitative phenotypes including susceptibility to disease. As such, it will directly benefit fundamental science via the discovery and classification of new molecules. Indirectly, it will lead to breakthroughs in biology, and consequently to major medical and pharmaceutical advances in the diagnosis and treatment of genetic disease.Read moreRead less
Problems of duality for semigroups and other algebras. The theory of natural dualities has emerged as a powerful tool in algebra and its applications, including logic, computer science and theoretical physics. The project aims to apply recently developed techniques to a particular class of mathematical objects of established application in areas such as automata and language theory; namely the class of semigroups. As well as the contribution to the theory of semigroups, the work will provide a ....Problems of duality for semigroups and other algebras. The theory of natural dualities has emerged as a powerful tool in algebra and its applications, including logic, computer science and theoretical physics. The project aims to apply recently developed techniques to a particular class of mathematical objects of established application in areas such as automata and language theory; namely the class of semigroups. As well as the contribution to the theory of semigroups, the work will provide an understanding of the limits and full potential of application of the general theory of natural dualities.Read moreRead less