Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Special Research Initiatives - Grant ID: SR0354623
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Network for Australian security technologies integration. The frontline of community safety is security technologies which include sensors to track movements and conversations of suspects; signal processing techniques for extracting information; intelligent search/audit techniques to track financial transactions; analysis techniques for predicting the spread of epidemic; and above all human factors in security operations. The aim of this initiative is to establish a network for "safeguarding Aus ....Network for Australian security technologies integration. The frontline of community safety is security technologies which include sensors to track movements and conversations of suspects; signal processing techniques for extracting information; intelligent search/audit techniques to track financial transactions; analysis techniques for predicting the spread of epidemic; and above all human factors in security operations. The aim of this initiative is to establish a network for "safeguarding Australia". This network, built on the concept of "network of networks", draws on the expertise of researchers and practitioners from diverse fields to provide an integrated approach towards development and use of security technologies for the safety of the community.Read moreRead less