Virtual transport networks. This project will develop specialised time-dependent networks for use in algorithmic software testing and development, focussing on public transportation networks, but applicable elsewhere. The virtual transport networks developed in this project will significantly reduce the cost of producing software products that perform network searches.
Secure and Dynamic Single Identification Systems. The expected results of the project will be frontier technologies that are essential in applications and services whose acceptance and take-up will be dependent on users' assurance of their privacy. Services, such as medical information or bank information, require a secure identification scheme. Securing such services will encourage new forms of collaboration among a wider range of users with the likely impact of a more productive global economy ....Secure and Dynamic Single Identification Systems. The expected results of the project will be frontier technologies that are essential in applications and services whose acceptance and take-up will be dependent on users' assurance of their privacy. Services, such as medical information or bank information, require a secure identification scheme. Securing such services will encourage new forms of collaboration among a wider range of users with the likely impact of a more productive global economy. This impact will be particularly emphasised in Australia with its geographically disperse population. Securing vital electronic transactions will ultimately contribute to lowering costs and increasing productivity and so creating a more competitive economy.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.
Faster, cheaper, better: mathematical advances for improved design and scheduling of robotic instrumentation. This project extends previous research addressing mathematical challenges in the optimal design and scheduling of robotic instrumentation. The Partner Organisation manufactures instruments for cancer diagnostics, and designs instruments that need to produce rapid, high-quality results, at a reasonable cost in a competitive market. It is intended that powerful new scheduling algorithms wi ....Faster, cheaper, better: mathematical advances for improved design and scheduling of robotic instrumentation. This project extends previous research addressing mathematical challenges in the optimal design and scheduling of robotic instrumentation. The Partner Organisation manufactures instruments for cancer diagnostics, and designs instruments that need to produce rapid, high-quality results, at a reasonable cost in a competitive market. It is intended that powerful new scheduling algorithms will be devised to handle their complex problem, which is more challenging than standard problems. The developed methodologies aim to reduce the product development cycle and boost the competitiveness of Australian manufacturers. In addition, new theoretical and algorithmic contributions aim to enable improved scheduling in other application areas.Read moreRead less
An integrated mathematical approach to synchronise and optimise hospital operations. This project aims to develop an integrated mathematical approach to synchronise and optimise patient scheduling systems of different departments to ensure that the hospital’s assets and related resources are used efficiently. The project’s aim is to investigate patient flow, process delay, and the interaction and inter-dependence of departments within the hospital to reduce access block (bottleneck) and subseque ....An integrated mathematical approach to synchronise and optimise hospital operations. This project aims to develop an integrated mathematical approach to synchronise and optimise patient scheduling systems of different departments to ensure that the hospital’s assets and related resources are used efficiently. The project’s aim is to investigate patient flow, process delay, and the interaction and inter-dependence of departments within the hospital to reduce access block (bottleneck) and subsequent overcrowding. This project aims to smooth the running of the hospital, improve the efficiency of patient throughput, reduce waiting times, and revolutionise hospital planning and scheduling.Read moreRead less
Optimisation of Rail Network Infrastructure Capacity under Dynamic Train Planning. Recent changes in railway operating environments have caused significant operational and management problems in Australia. This research will lead to improvements of railway's key managerial functions, namely: network capacity planning; rollingstock planning; train scheduling; and maintenance planning. The major outcome of the research will be to develop an optimisation model to significantly improve the operati ....Optimisation of Rail Network Infrastructure Capacity under Dynamic Train Planning. Recent changes in railway operating environments have caused significant operational and management problems in Australia. This research will lead to improvements of railway's key managerial functions, namely: network capacity planning; rollingstock planning; train scheduling; and maintenance planning. The major outcome of the research will be to develop an optimisation model to significantly improve the operating efficiency and assets productivity of Australia's rail system. The novelty of the research is that it will be undertaken using innovations based on modern job shop scheduling and sequencing optimisation techniques as the complexity of the problem makes it impossible to solve by classic optimisation techniques.Read moreRead less
Saving energy on trains - demonstration, evaluation, integration. Reducing energy use from rail transport will significantly contribute to cutting carbon dioxide emissions. This project will develop a toolkit to facilitate the introduction of in-cab technologies that help train drivers save energy and stay on time. The toolkit will make it easier to demonstrate, evaluate and integrate the system in a range of railways.
Application of Optimisation Techniques to the Truck/Loader Selection Problem in Mining. Australia has world class deposits of most major mineral commodities and is a major producer and exporter of coal and many metals. The mining industry has an annual turnover of around $40 billion. A significant component (up to 55%) of mining costs is material handling. This project aims to develop computational tools for determining the best selection of trucks and loaders for the mining operation. To da ....Application of Optimisation Techniques to the Truck/Loader Selection Problem in Mining. Australia has world class deposits of most major mineral commodities and is a major producer and exporter of coal and many metals. The mining industry has an annual turnover of around $40 billion. A significant component (up to 55%) of mining costs is material handling. This project aims to develop computational tools for determining the best selection of trucks and loaders for the mining operation. To date this important problem has not been addressed. Our strategy is to develop accurate mathematical models and cutting edge optimisation techniques for their solution. The research outcomes will have significant outcomes for the mining industry.Read moreRead less
Modelling the structure of Australian wool auction prices. Australian wool auction ($3.5-4 billions per year) is an on-going process. The prices paid in this auction market are used by the Australian production and service sectors to identify the quality preferences the international retail markets and the intermediate processors. The proposed research will optimise the information that can be extracted and used by these sectors in the production and distribution of the raw wool clip. A two- ....Modelling the structure of Australian wool auction prices. Australian wool auction ($3.5-4 billions per year) is an on-going process. The prices paid in this auction market are used by the Australian production and service sectors to identify the quality preferences the international retail markets and the intermediate processors. The proposed research will optimise the information that can be extracted and used by these sectors in the production and distribution of the raw wool clip. A two-stages algorithm in tree-based regression will be developed. The project will provide a challenge environment to train a Ph.D. student in agriculture modelling and optimisation.Read moreRead less