Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Normal And Abnormal Development Of Brain Wiring And Its Impact On Brain Function
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
My laboratory is striving to understand how the patterns of neuronal connections form in the developing brain and how these underpin the functions of the brain throughout life. We use high-field magnetic resonance imaging to measure brain wiring and we investigate the genetic and environmental mechanisms causing developmental brain disorders that result in intellectual disability, autism, epilepsy and some mental illnesses.
Centre For Research Excellence In Childhood Language
Funder
National Health and Medical Research Council
Funding Amount
$2,485,324.00
Summary
Although most children acquire speech and language skills comparatively effortlessly, it has become increasingly apparent that many do not. More importantly, this sizeable group accounts for great subsequent population health, social and economic burden. Research in the field has been underfunded and fragmented, resulting in evidence gaps, limited capacity, and disparate guidance for policy-makers. We will address these issues, acting as a vehicle and an ongoing catalyst for internationally-comp ....Although most children acquire speech and language skills comparatively effortlessly, it has become increasingly apparent that many do not. More importantly, this sizeable group accounts for great subsequent population health, social and economic burden. Research in the field has been underfunded and fragmented, resulting in evidence gaps, limited capacity, and disparate guidance for policy-makers. We will address these issues, acting as a vehicle and an ongoing catalyst for internationally-competitive research.Read moreRead less
Investigating and promoting resilience in children with intellectual disabilities. Disability is a significant risk factor that threatens health and well-being. For the estimated 4% of 0-14 year old children with diagnosed intellectual disabilities in Australia, early intervention is crucial for promoting resilience and preventing an accumulation of risk. By promoting resilience and thereby reducing the cost of lifelong support, evidence-based interventions produce huge social and economic benef ....Investigating and promoting resilience in children with intellectual disabilities. Disability is a significant risk factor that threatens health and well-being. For the estimated 4% of 0-14 year old children with diagnosed intellectual disabilities in Australia, early intervention is crucial for promoting resilience and preventing an accumulation of risk. By promoting resilience and thereby reducing the cost of lifelong support, evidence-based interventions produce huge social and economic benefits for the nation, as well as for individuals, families and communities.Read moreRead less
New information access technologies for people with intellectual disability. New information access technologies for people with intellectual disability. This project aims to co-design a social, interactive and visual internet search interface for people with intellectual disability. Enabling choice and independence is key to the new National Disability Insurance Scheme, but people with intellectual disability are effectively excluded from much of the Web. This project will investigate ways to a ....New information access technologies for people with intellectual disability. New information access technologies for people with intellectual disability. This project aims to co-design a social, interactive and visual internet search interface for people with intellectual disability. Enabling choice and independence is key to the new National Disability Insurance Scheme, but people with intellectual disability are effectively excluded from much of the Web. This project will investigate ways to access and provide information using technologies such as interactive avatars, virtual worlds and trusted social support. New interfaces will enable people with intellectual disability to inform themselves, make choices and foster their social inclusion. Expected outcomes are new search interface technology, a theoretical framework and new Web accessibility guidelines.Read moreRead less
Increasing organisational capacity of community residential units to facilitate ageing in place for people with intellectual disability. Unique challenges face the disability, aged care and health sectors because of the increased life expectancy of people with life-long intellectual disability (ID) and the likelihood of their premature ageing. Although this group is recognised by Federal and State governments as requiring specific and special service arrangements, little is known about adapting ....Increasing organisational capacity of community residential units to facilitate ageing in place for people with intellectual disability. Unique challenges face the disability, aged care and health sectors because of the increased life expectancy of people with life-long intellectual disability (ID) and the likelihood of their premature ageing. Although this group is recognised by Federal and State governments as requiring specific and special service arrangements, little is known about adapting disability and aged care services to their needs. This research will inform the development of policy and programs in the disability, aged care, and health sectors. The research aims to improve the capacity of disability group homes to respond to the health and ageing issues of older people with ID,to improve their quality of life.Read moreRead less
Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population a ....Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population and people with bone abnormalities.Read moreRead less
Constructing futures: an investigation of the aspirations of young adults with an intellectual disability and their parents. This project aims to develop a better understanding of the aspirations for adult life held by young adults with an intellectual disability and their parents. Organisations that provide services to this vulnerable group will use the results to examine current, and guide future, service provision.
Consumer value and disability services: The impact of increased autonomy. This project seeks to explore a key question of the National Disability Insurance Scheme (NDIS): will service provision improve when service users have the ability to choose? In 2016, the NDIS will start rolling out and nearly half a million people with a disability will be able to choose disability services. The project aims to identify changes in objective and perceived consumer value pre-NDIS and post-NDIS, and differen ....Consumer value and disability services: The impact of increased autonomy. This project seeks to explore a key question of the National Disability Insurance Scheme (NDIS): will service provision improve when service users have the ability to choose? In 2016, the NDIS will start rolling out and nearly half a million people with a disability will be able to choose disability services. The project aims to identify changes in objective and perceived consumer value pre-NDIS and post-NDIS, and differences in how market segments use their autonomy and whether this leads to differences in benefits gained from the NDIS. Findings are intended to contribute to a better understanding of when free market mechanisms serve the needs of their citizens better than traditional means of government support.Read moreRead less
A Centre For Research Excellence In Cerebral Palsy (CRE-CP)
Funder
National Health and Medical Research Council
Funding Amount
$2,622,042.00
Summary
Cerebral palsy is the most common physical disability in childhood. Our objective is to bring about a radical improvement in the treatment of individuals with cerebral palsy, both children and adults, and to determine better ways to assist their families. Emphasis will be placed on early detection of health issues and rigorous evaluation of management options. We will train more researchers and ensure that all the knowledge generated is made available to families and health care professionals.