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Use Of Oral Enzymes To Treat Carbohydrate Intolerance: Adjunct Therapy To The Low FODMAP Dietary Treatment Of Irritable Bowel Syndrome.
Funder
National Health and Medical Research Council
Funding Amount
$610,197.00
Summary
Irritable bowel syndrome (IBS) is a common disorder affecting 1 in 7 Australians and fermentation of poorly digested short chain carbohydrates are major dietary triggers. The lack of certain digestive enzymes is a major reason why some carbohydrates are not digested. This project will explore the potential use of oral enzyme supplements to assist with the digestion of these indigestible carbohydrates with the potential for use as adjunct therapy to treat gut symptoms associated with IBS.
The Role Of Wheat Gluten In The Genesis Of Gastrointestinal Symptoms And Fatigue In Patients With Non-coeliac Gluten Intolerance.
Funder
National Health and Medical Research Council
Funding Amount
$686,242.00
Summary
Currently �gluten- and wheat-intolerances� are poorly recognised by the medical profession and yet many Australians who do not have coeliac disease claim to be wheat- or gluten-intolerant. The most common complaints relate to chronic fatigue and gut symptoms such as wind and bloating. Our research team have new and recent evidence that wheat-gluten does trigger symptoms in some patients who suffer from Irritable Bowel Syndrome. This project aims to improve our understanding in this area.
Regulation Of Mutational Load By Chemopreventive Agents And Implications For Molecular Pathogenesis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$423,750.00
Summary
In Australia colorectal cancer is the second most common cause of cancer death, however the morbidity and mortality of colorectal cancer is currently not under control. Identification of safe and practical preventive agents should aid control. There is increasing evidence that colorectal cancer is associated with endogenous (internall) and exogenous (external) factors. They cause damage to DNA which might lead to tumour development if the damage is not repaired. This study will first identify th ....In Australia colorectal cancer is the second most common cause of cancer death, however the morbidity and mortality of colorectal cancer is currently not under control. Identification of safe and practical preventive agents should aid control. There is increasing evidence that colorectal cancer is associated with endogenous (internall) and exogenous (external) factors. They cause damage to DNA which might lead to tumour development if the damage is not repaired. This study will first identify the ability of preventive agents (aspirin-like drugs, fish oil, and antioxidants) to regulate DNA damage, then examine the effect of combination of the agents. It will finally determine the ability of agents, or combination of agents, to prevent development of colorectal cancer using two animal models. Prevention of human CRC by such a strategy should be feasible. First, evidence indicates that DNA damage is important in tumour initiation. Second, exogenous regulation of DNA damage, repair and removal seems possible. Epidemiological studies have suggested that that 30-70% of cancer can potentially be prevented with proper adjustment of diets (fat, fibre, resistant starch) and supplements of drugs (NSAIDs) or antioxidants (Vitamin, Selenium). Third, preventive strategies are likely to be feasible. At the population level, they would need to be safe and manageable in the context of dietary lifestyle, but this can be achieved through a range of food technology developments. In individuals at high risk, personalised preventive strategies become feasible through doctor-patient contact. This study focuses on regulation of DNA damage, and its repair and removal during the early stage of tumour development. The study will provide information if preventive agents, alone or in combination, provide a promising strategy for colorectal cancer through reduction of genetic damage. They might also identify new biomarkers that facilitate testing in humans.Read moreRead less