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Fat Sensing In The Gut: Role In Appetite Regulation In Health And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$391,076.00
Summary
Dr Little has an international reputation for her research relating to the sensing of nutrients in the gut. During the next 4 years her goal is to establish herself as an independent researcher leading a team and program focussed on characterising the molecular and physiological mechanisms by which fat is sensed in the gut, and the role of these mechanisms in energy intake regulation in health and obesity. These insights are likely to result in more effective management strategies for obesity.
Building Evidence To Improve Health Through Optimal Diet
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
This research will focus on dietary patterns in population health across the life-course. We know little about how dietary patterns and their determinants vary across life and the impact of life-stage transitions on diet and health. This research will provide unique insights into dietary patterns of infants, children, young adults and older adults.
International Strategies To Reduce Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Effective, sustainable and scalable strategies to reduce salt are needed so countries can achieve the global target to reduce salt by 30% by 2025. This research program will support the optimal development of such strategies through trials and intervention research projects, supplemented through a series of systematic reviews and feasibility and cost-effectiveness assessments. The main outcome will be new evidence on the effectiveness of different interventions to support translation globally.
Mechanistic And Translational Studies Of A New Therapeutic For The Treatment Of Obesity And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Diabetes develops when beta-cells are no longer able to secrete enough insulin to control blood glucose. This research project will identify factors which regulate beta-cell function and identify means of regulation.
The Impact Of Sleep Disturbance On Cardiometabolic Function
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strate ....Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strategies that could improve health in shiftworkers.Read moreRead less
The Molecular Mechanism Of Ion-coupled Transport In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$441,407.00
Summary
Cells in the brain communicate through chemical signals called neurotransmitters. Neurotransmitter transporters reside in the membranes of cells and are responsible for regulating levels of these chemicals in the brain. They play an important role in the normal function of the human brain but their dysfunction is responsible for many diseases including Alzheimer's disease and motor neuron disease. It is crucial to understand how these proteins work in both normal and disease states.
Reducing Over Consumption Of Sugar-sweetened Beverages In Australia
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
Sugar-sweetened beverage (SSB) consumption is associated with excess energy intake, weight gain and obesity. High consumption also causes Type II diabetes, cardio vascular risk factors and tooth decay. Australians, especially young Australians, are high consumers of SSBs, and soft drinks in particular. Bringing experience from tobacco control, this research investigates public health policy mechanisms to reduce over consumption, with a focus on the potential of warning labels.