Cardiometabolic Risk Trajectories From Childhood To Midlife: Finding Pathways To Better Health
Funder
National Health and Medical Research Council
Funding Amount
$1,531,987.00
Summary
Using data from a large cohort of Australian children followed for over 30 years, this study will investigate how weight status and physical fitness from childhood to adulthood determine early markers of cardiovascular disease and type 2 diabetes (cardiometabolic disease) in midlife. It will provide much needed evidence to address the high prevalence of cardiometabolic disease risk factors in young Australians through better targeted disease prevention and early clinical intervention strategies.
The Effect Of Cytochrome P450 Genotype On Blood Pressure And 20-HETE Responses To Lifestyle Interventions
Funder
National Health and Medical Research Council
Funding Amount
$743,665.00
Summary
The effectiveness of treatments to reduce heart disease risk can vary enormously between individuals. This is partly due to a persons genetic makeup. Fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450-AAM) can act on blood vessels and the kidney to regulate blood pressure. We will study the effect of having a variation in a gene that regulates CYP450-AAM on blood pressure and heart disease risk in combination with a high salt diet or weight reduction.