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E. coli is a normal inhabitant of the human intestine, but some varieties can cause serious infections that may lead to the premature death of children, especially in less developed countries. The aims of this study are to learn more about these harmful varieties of E. coli and to enhance our ability to detect them in samples from patients and the environment.
My research team is focused on human parasites of major relevance to the Australian water industry and/or global public health. Our primary focus is the use of advanced technologies to improve understanding of these parasites and to utilize this information to underpin development of new drugs to treat them and novel diagnostic tests to improve their control.
Combating E. Coli Diarrhoea By Disarming Bacterial Virulence
Funder
National Health and Medical Research Council
Funding Amount
$674,737.00
Summary
E. coli causes severe and persistent diarrhoea which affects the health of millions of people worldwide. Although antibiotics may alleviate E. coli diarrhoea, these bacteria are becoming resistant to most drugs. In this study, we will use state-of-the-art technology to discover novel types of drug that treat and prevent infection with E. coli, without harming the beneficial bacteria in the gut.
Identifying Pragmatic Strategies To Prevent And Treat Enteric Infection In Indigenous Infants
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Diarrhoea remains one of the commonest causes of death in young children. Most of these deaths occur in places that have limited clean water, food, and health care. Although deaths from diarrhoea are rare in Australia, Indigenous children still suffer from frequent and severe episodes of diarrhoea, much more so that than non-Indigenous infants. This research aims to reduce this suffering by finding ways to both prevent and treat diarrhoea in young children.
Improving Access To Safe Water Using Riverbank Filtration Technology
Funder
National Health and Medical Research Council
Funding Amount
$1,056,616.00
Summary
Diarrhoea is a leading cause of death and disease globally, most often due to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) uses natural treatment processes to improve water quality. This project will investigate the effect of improving water quality via installation of RBF systems on diarrhoea incidence in six rural Indian communities.
Characterisation Of Rotavirus Vaccine Escape - Potential For Significant Impact On Vaccination Program
Funder
National Health and Medical Research Council
Funding Amount
$531,689.00
Summary
The introduction of rotavirus vaccines have had enormous impact on improving the health of children worldwide. However, the emergence of vaccine escape strains has the potential to significantly reduce the vaccine effectiveness. This study proposes to characterise strains able to escape vaccine protection.
Investigating The Incremental Health Benefits Of Improving Water Quantity Versus Improving Water Quality Using Riverbank Filtration Technology (RBF) In Six Rural Communities In India
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Diarrhoea is a leading cause of death and disease globally, largely attributable to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) is an inexpensive means to improve water quality. This project will investigate the health benefits of improving water quantity versus improving water quality using RBF technology in six rural Indian communities.
Class-specific Virulence Determinants Of Atypical Enteropathogeneic E. Coli
Funder
National Health and Medical Research Council
Funding Amount
$672,134.00
Summary
Some varieties of E. coli cause diarrhoea, but they are difficult to diagnose in the laboratory. The aim of this study is to find specific genes of disease-associated E. coli that could be used as targets to identify these bacteria in patients with diarrhoea. The discovery of genes from E. coli that could be used as diagnostic targets will provide invaluable tools to study the epidemiology and clinical impact of these bacteria in patients in Australia and overseas.