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Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protei ....Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protein self-assembly and will have application outcomes that contribute to Australia being an important player in the field of nanotechnology. This is critical for Australia's long term competitiveness and productivity in and beyond the 21st century.Read moreRead less
Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they sh ....Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they should provide significant advantages over conventional detection strategies. These advantages include increased sample throughput and conservation of biological samples, which makes possible the acceleration of patient diagnosis and drug discovery. Read moreRead less
Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery an ....Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery and therefore health outcomes for Australia. The interdisciplinary nature of this project will also result in a unique training program for the researchers involved. Such experience is in great demand in Australia where the developing biotechnology and nanotechnology industry is critically short of scientists with skills in drug delivery.Read moreRead less
Construction and Use of Yoctowells as Vessels for Catalysis, Sensing and Artificial Photosynthesis. Yoctowell recognition systems are likely to form the basis of a new generation of biosensors, high throughput screening systems for identification of nucleotides and as energy transduction systems. As a result, this research will be relevant to technological advances in the areas of biotechnology and nanotechnology. Researching functional yoctowells containing photoactive and redox-active componen ....Construction and Use of Yoctowells as Vessels for Catalysis, Sensing and Artificial Photosynthesis. Yoctowell recognition systems are likely to form the basis of a new generation of biosensors, high throughput screening systems for identification of nucleotides and as energy transduction systems. As a result, this research will be relevant to technological advances in the areas of biotechnology and nanotechnology. Researching functional yoctowells containing photoactive and redox-active components will contribute to the major effort in basic research on smart optoelectric that are needed today to meet tomorrow's energy demands in a sustainable way. Read moreRead less
Design of Novel Polymer Micro-Porous Coatings. This project utilises unique polymer structures that self-organise into highly-ordered polymer films. These polymer films have arrays of pores with pore diameters on the micron scale. These films are suitable for high-technology membranes applications, in for instance, biosensors.
Novel Hydrogels for Bioseparations in Clinical Applications. The project aims to design and synthesise new highly swollen hydrophilic membranes for use in biological separation processes and purifications such as the removal of viruses from blood. Typical membrane problems like membrane fouling or low flux should be minimized by a narrow pore size distribution. The regular nano-patterning should be obtained by molecular impriniting technique. Novel thermoresponsive polymers, which will be polyme ....Novel Hydrogels for Bioseparations in Clinical Applications. The project aims to design and synthesise new highly swollen hydrophilic membranes for use in biological separation processes and purifications such as the removal of viruses from blood. Typical membrane problems like membrane fouling or low flux should be minimized by a narrow pore size distribution. The regular nano-patterning should be obtained by molecular impriniting technique. Novel thermoresponsive polymers, which will be polymerized via controlled free radical polymerization techniques, will be used as biocompatible membrane material.Read moreRead less
Design of Polymeric Devices for Biotechnological Applications. The research project focuses on the development of functional polymer particles for diagnostic applications. Advanced polymer chemistry will be used to synthesize devices for reliable and fast diagnostic systems. The outcome of this work will help promoting and maintaining good health in Australia by developing novel technologies and advanced materials based on polymer science.
Polymer Stabilized and Bio-functionalised Metal Nanoparticles As Potential Vectors For Drug Therapies. The project aims to make novel nanoparticles (extremely small, nano means one billionth of a metre) that carry medicines to very specific sites of the body and then release them. This would result in much improved outcomes for conventional chemotherapy but may also allow new gene therapies where diseases can be silenced at their source.
Discovery Early Career Researcher Award - Grant ID: DE180100669
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
Upconversion nanothermometry: enabling high brightness in a thermal field. This project aims to create a unique library of nanometer scale temperature-responsive sensors for bio-discoveries, disease diagnostics, device manufacturing and anti-counterfeiting, by investigating a new observation in enhanced photon energy conversion. The project will develop a thermal-field diagnostics approach to reveal interfacial cation-ligand behaviours of luminescent hybrid nanomaterials, and modify the otherwis ....Upconversion nanothermometry: enabling high brightness in a thermal field. This project aims to create a unique library of nanometer scale temperature-responsive sensors for bio-discoveries, disease diagnostics, device manufacturing and anti-counterfeiting, by investigating a new observation in enhanced photon energy conversion. The project will develop a thermal-field diagnostics approach to reveal interfacial cation-ligand behaviours of luminescent hybrid nanomaterials, and modify the otherwise quenching molecules to facilitate energy upconversion. This will link surface chemistry and heterogeneous interfacial physics. It will allow ratiometric fluorescence to achieve extremely high sensing sensitivity in intracellular nanothermometry, enabling super resolution thermal imaging of living cells.Read moreRead less
Investigations into the Versatility of Peptide Nucleic Acid Conjugates. Neurodegeneration and cancer are two of the greatest frontiers in modern medicine. They impose significant medical, financial and social burdens on sufferers, carers and the wider community. Novel technologies with the ability to help diagnosis, enlighten researchers to the biological principles governing the disease and that can make a contribution to prevention, quality of life issues and survival of sufferers are of utmos ....Investigations into the Versatility of Peptide Nucleic Acid Conjugates. Neurodegeneration and cancer are two of the greatest frontiers in modern medicine. They impose significant medical, financial and social burdens on sufferers, carers and the wider community. Novel technologies with the ability to help diagnosis, enlighten researchers to the biological principles governing the disease and that can make a contribution to prevention, quality of life issues and survival of sufferers are of utmost importance. This project aims to make a significant contribution to these areas using antisense technologies against some previously studied targets.Read moreRead less