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LIPID AND LIPOPROTEIN ADSORPTION AT BIOMATERIALS AND BIO-DIAGNOSTICS INTERFACES. This project aims to investigate molecular mechanisms involved in the formation of undesired biological deposits on synthetic materials and thereby help establish the scientific basis for the rational design of materials with improved compatibility with biological fluids and the engineering of a new generation of biomedical implant devices and bio-diagnostic devices. It is well known that proteins accumulate on synt ....LIPID AND LIPOPROTEIN ADSORPTION AT BIOMATERIALS AND BIO-DIAGNOSTICS INTERFACES. This project aims to investigate molecular mechanisms involved in the formation of undesired biological deposits on synthetic materials and thereby help establish the scientific basis for the rational design of materials with improved compatibility with biological fluids and the engineering of a new generation of biomedical implant devices and bio-diagnostic devices. It is well known that proteins accumulate on synthetic solid surfaces. This project proposes to investigate whether lipids and lipoproteins also play key roles in the initiation of biological adsorption processes. Combined with the study of the interfacial forces responsible, this information will guide the design of preventative strategies.Read moreRead less
In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes ....In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes have on protein structure, function hence disease.Read moreRead less
Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Aus ....Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Australian community by providing technology which will allow rapid and inexpensive monitoring of water as well as biomedical diagnosis. The research will also benefit Australia via providing the training of scientists to establish the new generation of Australia's bionanotechnology industry. Read moreRead less
Making Silicon Even More Useful: Functionalising Silicon to Produce Stable Electronic Devices in Aqueous Environments. Silicon is the wonder material of our time, being the foundation upon which our electronics and device industries are based. Silicon however would be even more useful if it could be stabilised so the surface did not oxidise in air and water. If this oxidation could be prevented silicon could be used in a whole range of new devices related to biotechnology, molecular electronics ....Making Silicon Even More Useful: Functionalising Silicon to Produce Stable Electronic Devices in Aqueous Environments. Silicon is the wonder material of our time, being the foundation upon which our electronics and device industries are based. Silicon however would be even more useful if it could be stabilised so the surface did not oxidise in air and water. If this oxidation could be prevented silicon could be used in a whole range of new devices related to biotechnology, molecular electronics and sensing. The project will develop a viable surface chemistry strategy for achieving this stabilisation and hence will greatly expand the scope of devices which can be fabricated from silicon. This will have significant scientific and economic benefits for Australia. We will exploit this new capability for cancer detection, cell engineering and biosensing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347970
Funder
Australian Research Council
Funding Amount
$186,000.00
Summary
Integrated Bio-nano-fabrication Facility. The project proposes the upgrade of a joint facility for the probing, fabrication and operation of hybrid bio-nano-devices. The facility will enhance the proposers' capabilities in the area of the fundamental and prototype-type research on biomolecular/cellular devices. The ultimate goal of these projects is to thrust Australian science in the era when the essential functions of cells can be replicated and controlled on devices that are smaller than livi ....Integrated Bio-nano-fabrication Facility. The project proposes the upgrade of a joint facility for the probing, fabrication and operation of hybrid bio-nano-devices. The facility will enhance the proposers' capabilities in the area of the fundamental and prototype-type research on biomolecular/cellular devices. The ultimate goal of these projects is to thrust Australian science in the era when the essential functions of cells can be replicated and controlled on devices that are smaller than living cells. The proposed facility has a modular structure consisting of additional nano-positioning, confocal microscope and zeta potential modules built on the existent laser tweezers/scissors, picoliter pipette and Atomic Force Microscope modules.Read moreRead less
A Generic Solution for Interfacing Electrodes with Biological Media. Electrodes are the critical element of stimulating implantable devices such as cardiac pacemakers, bionic eyes and cochlear implants, the most commercially successful biosensors, and are emerging as key to new technologies for testing new drug leads using cells. In all these applications of electrodes in biology there has never been a solution to stopping unwanted adsorption of biological material onto the electrode that does ....A Generic Solution for Interfacing Electrodes with Biological Media. Electrodes are the critical element of stimulating implantable devices such as cardiac pacemakers, bionic eyes and cochlear implants, the most commercially successful biosensors, and are emerging as key to new technologies for testing new drug leads using cells. In all these applications of electrodes in biology there has never been a solution to stopping unwanted adsorption of biological material onto the electrode that does not dramatically decrease electrode performance. The proposed research finally provides a solution via surface modification. This strategy will enhance the performance of all the devices above and will open doors to new applications of electrochemistry within biology.Read moreRead less
Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the ....Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the condition to fabricate biological devices such as immune sensors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775612
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the de ....Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the development of next-generation medicines, implants, optical devices and surface coatings, further strengthening Australia's formidable reputation in these areas.Read moreRead less
Surface Chemistry meets Cell Biology: Molecular Level Control of Surface Architecture for Cell Adhesion and Migration. Biotechnological applications such as tissue engineering, bone supports, implantable materials, cell assays and biosensors all require detailed knowledge of how cells interact with their environment. The proposed research aims to provide this knowledge by developing unique modified surfaces to investigate white blood cell migration and adhesion. Additional expected outcome will ....Surface Chemistry meets Cell Biology: Molecular Level Control of Surface Architecture for Cell Adhesion and Migration. Biotechnological applications such as tissue engineering, bone supports, implantable materials, cell assays and biosensors all require detailed knowledge of how cells interact with their environment. The proposed research aims to provide this knowledge by developing unique modified surfaces to investigate white blood cell migration and adhesion. Additional expected outcome will contribute to our understanding of the many fundamental cellular processes such as cell growth, differentiation and cell death as well as the molecular basis of diseases such as inflammation, cancer, cardiovascular diseases and wound healing. This research program will establish Australia as a leading force in this new research field.Read moreRead less
Nanotherapeutics: nanoparticles with high specificity for the delivery and controlled release of drugs. This technology will deliver therapeutic drugs and/or MRI contrast agents to individual diseased cells with very high specificity and selectivity. The cells can be interogated to determine when they are "loaded" and the site of the "loaded" cells precisely determined. Drugs can be released photochemically. The administered dosage can be decreased with no loss of efficacy, and side effects re ....Nanotherapeutics: nanoparticles with high specificity for the delivery and controlled release of drugs. This technology will deliver therapeutic drugs and/or MRI contrast agents to individual diseased cells with very high specificity and selectivity. The cells can be interogated to determine when they are "loaded" and the site of the "loaded" cells precisely determined. Drugs can be released photochemically. The administered dosage can be decreased with no loss of efficacy, and side effects reduced. Read moreRead less