Development Of A Novel Biosensor Using Magnetically Amplified Luminescence For The Early Detection Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$267,500.00
Summary
Cancer is often not detected until it has invaded surrounding tissues and spread to other organs. Current treatment is then often ineffective, and prognosis poor. Early detection of cancer is therefore essential for improved disease management. Such methods must be cheap, non-invasive, and rapid with high sensitivity and specificity. We are investigating a new biosensor technology that satisfies these criteria. This method uses magnetically amplified luminescence for the detection of low levels ....Cancer is often not detected until it has invaded surrounding tissues and spread to other organs. Current treatment is then often ineffective, and prognosis poor. Early detection of cancer is therefore essential for improved disease management. Such methods must be cheap, non-invasive, and rapid with high sensitivity and specificity. We are investigating a new biosensor technology that satisfies these criteria. This method uses magnetically amplified luminescence for the detection of low levels of cancer cells in clinical samples (urine, faeces, blood, biopsy), using telomerase as a marker.Read moreRead less
Micropapillary Adenocarcinoma: The Emergence Of A Discrete Lung Cancer Phenotype And Its Genomic And Transcriptomic Characterization.
Funder
National Health and Medical Research Council
Funding Amount
$117,565.00
Summary
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Oxidation Of Mismatch: A New Concept For Mutation Detection Which Avoides A Separation Method In Mutation Scanning
Funder
National Health and Medical Research Council
Funding Amount
$143,000.00
Summary
Detection of faults (mutations) in genes is expensive but essential for proper genetic health care. Because of the cost of such tests many people are not diagnosed either through diagnostic labs or research of the cost of such tests many people are not diagnosed either through diagnostic labs or research projects. Such research projects are inhibited due to the complexity of the current methods. Current methods are complex and expensive, especially looking for a possible fault, due to what is ca ....Detection of faults (mutations) in genes is expensive but essential for proper genetic health care. Because of the cost of such tests many people are not diagnosed either through diagnostic labs or research of the cost of such tests many people are not diagnosed either through diagnostic labs or research projects. Such research projects are inhibited due to the complexity of the current methods. Current methods are complex and expensive, especially looking for a possible fault, due to what is called a preparation step on complex and expensive equipment. We will develop and commercialise a simpler test because separation is avoided.Read moreRead less
To Apply Evidence Based Practice To Optimise The Laboratory Diagnosis Of Muscular Dystrophies
Funder
National Health and Medical Research Council
Funding Amount
$82,642.00
Summary
Currently in Australia, muscular dystrophy diagnosis entails detailed biochemical analyses mainly performed within research laboratories. We will use evidence based practice to optimise the laboratory diagnosis of muscular dystrophies, and provide information for genetic and clinical counselling and prevention to improve the standard of service for those with the disease. Assessment of diagnostic efficacy and cost-efficiency will aid in evaluating diagnostic approaches for other rare disorders.
Loop-mediated Isothermal Amplification(LAMP): A Novel Tool For The Diagnosis Of Mixed Malaria Infections In Elimination Settings
Funder
National Health and Medical Research Council
Funding Amount
$101,877.00
Summary
The malaria elimination agenda will require the development of novel, field applicable diagnostic tools to detect asymptomatic carriers of P.falciparum and non-falciparum malaria infections. Loop-mediated isothermal amplification (LAMP) has been demonstrated to be a novel, sensitive, specific nucleic acid amplification technique. My project aims to optimise LAMP into a high-throughput field applicable molecular diagnostic tool capable of diagnosing malaria in elimination settings
Advanced Technologies For Improved Molecular Diagnostic And Prognostic Of Gastrointestinal Cancers
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
The aim of this interdisciplinary research is to develop innovative and clinically relevant technologies for improved molecular diagnostic of gastrointestinal cancers. It integrates technological advances in physics, bioengineering and nanoscience with state-of-the-art molecular technologies towards the delivery of both fundamental and translational outcomes. These technologies will be applied to address important fundamental questions such as the role of circulating tumour cells.
Tackling Urgent Antimicrobial Resistance Threats In Australia—in Action
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Antimicrobial resistance is a major global concern, there are limited new treatment options and current resistance surveillance practices have limitations. As a part of this fellowship I will collaborate with industry partners, utilise geographical mapping and novel DNA sequencing technologies with a view to enhance resistance surveillance for gonorrhoea and other public health threats, inform new treatment strategies and better understand the spread of gonorrhoea in the population.