Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453879
Funder
Australian Research Council
Funding Amount
$184,163.00
Summary
Electron beam induced deposition and ablation nanofabrication facility. Electron beam induced deposition and ablation(EBIDA) is rapidly emerging as a new technology capable of fabricating three-dimensional nanostructures on nearly any substrate with very high precision. This proposal aims to establish a nanoscale EBIDA facility by integrating a specialized nanolithography attachment with an existing state-of-the-art 1nm resolution high current variable pressure scanning electron microscope. This ....Electron beam induced deposition and ablation nanofabrication facility. Electron beam induced deposition and ablation(EBIDA) is rapidly emerging as a new technology capable of fabricating three-dimensional nanostructures on nearly any substrate with very high precision. This proposal aims to establish a nanoscale EBIDA facility by integrating a specialized nanolithography attachment with an existing state-of-the-art 1nm resolution high current variable pressure scanning electron microscope. This combination of instrumentation will enable the high-speed production of conductive and insulating structures with 1-to-10nm dimensions. The unique facility will be used to manufacture and prototype novel nanoscale devices and structures and will enable measurement of their physical and chemical properties.Read moreRead less
Development of direct-write focussed electron beam processing techniques for nano-fabrication applications. The burgeoning disciplines of nanotechnology and biotechnology have the potential to deliver breakthroughs in science and engineering that will revolutionise many aspects of everyday life. Progress in these emerging fields, however, requires parallel advances in the techniques used to fabricate, manipulate and characterise materials and devices at the nanoscale. This project will provide s ....Development of direct-write focussed electron beam processing techniques for nano-fabrication applications. The burgeoning disciplines of nanotechnology and biotechnology have the potential to deliver breakthroughs in science and engineering that will revolutionise many aspects of everyday life. Progress in these emerging fields, however, requires parallel advances in the techniques used to fabricate, manipulate and characterise materials and devices at the nanoscale. This project will provide such enabling tools and fill a major gap in the research infrastructure urgently required by these exciting new technologies.Read moreRead less
Development of a Novel and Quantitative Approach to Phase Imaging with Applications to Functional Nanomaterials. This project will improve and apply an innovative approach to obtaining phase information from electron microscopy images, currently being commercialised by IATIA Ltd. We will develop the approach so that it is fully quantitative, even at the nanoscale, and explore the effect of experimental parameters such as beam coherence, aberrations, specimen contamination and diffraction. We wil ....Development of a Novel and Quantitative Approach to Phase Imaging with Applications to Functional Nanomaterials. This project will improve and apply an innovative approach to obtaining phase information from electron microscopy images, currently being commercialised by IATIA Ltd. We will develop the approach so that it is fully quantitative, even at the nanoscale, and explore the effect of experimental parameters such as beam coherence, aberrations, specimen contamination and diffraction. We will apply the method to both physical and molecular nanomaterials, including a new class of self-organising molecules. Phase imaging can visualise the structures, polarities, charge and conductivity distributions in these materials and so assist in the development of new materials and devices.Read moreRead less
Nanoparticle fluorescent labels as a platform for high throughput data gathering. Recent developments in genomics require gathering of vast amounts of information in a rapid and cost-effective fashion. To this aim we will develop a new fluorescent labelling technology with adequate throughput and high level of multiplexing. We will exploit recent advances in nanoparticle science combined with our own discoveries concerning rare earth ions as fluorescence activators. Our approach promises a combi ....Nanoparticle fluorescent labels as a platform for high throughput data gathering. Recent developments in genomics require gathering of vast amounts of information in a rapid and cost-effective fashion. To this aim we will develop a new fluorescent labelling technology with adequate throughput and high level of multiplexing. We will exploit recent advances in nanoparticle science combined with our own discoveries concerning rare earth ions as fluorescence activators. Our approach promises a combination of great technological simplicity, low fabrication costs, cutting edge performance and gives an additional time-resolved modality. Our fluorescent labels will be field-tested to search for yet unknown microorganisms.Read moreRead less
Quantitative Atom Probe Tomography for Nanostructural Analysis of Materials. The ultimate in microscopy would involve the ability to image and chemically identify every atom or molecule in a specimen. This project involves the development of reconstruction and analysis methodologies for more accurately determining relative atomic positions in atom probe tomography. We will develop a comprehensive, platform-independent approach to enable quantitative atom probe tomography for the Australian resea ....Quantitative Atom Probe Tomography for Nanostructural Analysis of Materials. The ultimate in microscopy would involve the ability to image and chemically identify every atom or molecule in a specimen. This project involves the development of reconstruction and analysis methodologies for more accurately determining relative atomic positions in atom probe tomography. We will develop a comprehensive, platform-independent approach to enable quantitative atom probe tomography for the Australian research community. This development will be used to address current questions on the influence of the chemistry, crystallography, type and dispersion of sub-critical atomic clusters and supra-critical nanoscale precipitates on the strengthening mechanisms in light alloys used for structural applications in transport.Read moreRead less
Development of a light detection system for enhanced scanning electron microscopy imaging of fully hydrated biological specimens at room temperature. This project aims to develop instrumentation and techniques to image fully hydrated cellS for prolonged periods at room temperature in an environmental scanning electron microscope. Multiple fluorescent nano-particle labels will be used to image complex cellular structure and dynamics at ultra high spatial resolution. This innovative bio-imaging te ....Development of a light detection system for enhanced scanning electron microscopy imaging of fully hydrated biological specimens at room temperature. This project aims to develop instrumentation and techniques to image fully hydrated cellS for prolonged periods at room temperature in an environmental scanning electron microscope. Multiple fluorescent nano-particle labels will be used to image complex cellular structure and dynamics at ultra high spatial resolution. This innovative bio-imaging technique will be facilitated by the construction of a high speed light collection system that can efficiently operate at the pressures required to stablise water within the cell. Applications for this new bio-imaging technique will also be explored.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560850
Funder
Australian Research Council
Funding Amount
$295,320.00
Summary
Scanning Cathodoluminescence Microscopy and Spectroscopy Facility. Cathodoluminescence (CL), the emission of light during electron irradiation, has emerged as a unique analytical tool to characterise luminescence centres and study luminescence mechanisms in technologically important materials at the nano-scale. The main aim of this project is to establish a state-of-the-art scanning CL microscopy and spectroscopy facility in Australia. The facility will enable high spatial resolution CL analysis ....Scanning Cathodoluminescence Microscopy and Spectroscopy Facility. Cathodoluminescence (CL), the emission of light during electron irradiation, has emerged as a unique analytical tool to characterise luminescence centres and study luminescence mechanisms in technologically important materials at the nano-scale. The main aim of this project is to establish a state-of-the-art scanning CL microscopy and spectroscopy facility in Australia. The facility will enable high spatial resolution CL analysis of technologically important semiconductors and novel nano-structured materials, e.g. quantum dots and ceramic nano-crystals. These studies will facilitate a deeper understanding of the physics of light emission from nano-structured materials and enable the fabrication of higher quality opto-electronic materials.Read moreRead less
Mapping electronic structure and material properties with atomic resolution. This project will use electron energy loss spectroscopy (EELS) to map the bonding and electronic structure of InGaN quantum wells at the atomic scale. We will measure and correlate the local composition, strain and electronic structure variations within the wells in order to understand the optical emission in this system. The characterisation tools developed will allow us to go beyond measuring structure and composition ....Mapping electronic structure and material properties with atomic resolution. This project will use electron energy loss spectroscopy (EELS) to map the bonding and electronic structure of InGaN quantum wells at the atomic scale. We will measure and correlate the local composition, strain and electronic structure variations within the wells in order to understand the optical emission in this system. The characterisation tools developed will allow us to go beyond measuring structure and composition and map properties of nano-materials at the atomic scale.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less