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To Apply Evidence Based Practice To Optimise The Laboratory Diagnosis Of Muscular Dystrophies
Funder
National Health and Medical Research Council
Funding Amount
$82,642.00
Summary
Currently in Australia, muscular dystrophy diagnosis entails detailed biochemical analyses mainly performed within research laboratories. We will use evidence based practice to optimise the laboratory diagnosis of muscular dystrophies, and provide information for genetic and clinical counselling and prevention to improve the standard of service for those with the disease. Assessment of diagnostic efficacy and cost-efficiency will aid in evaluating diagnostic approaches for other rare disorders.
Micropapillary Adenocarcinoma: The Emergence Of A Discrete Lung Cancer Phenotype And Its Genomic And Transcriptomic Characterization.
Funder
National Health and Medical Research Council
Funding Amount
$117,565.00
Summary
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Using Epidemiology To Inform Psychiatric Classification (DSM-V And ICD-11)
Funder
National Health and Medical Research Council
Funding Amount
$631,502.00
Summary
Classification systems are vital for scientific progress. The classifications of mental disorders of the World Health Organization and the American Psychiatric Association are both being revised and this Australian team is a principal contributor to both processes. We have access to three national epidemiological surveys (n-30,000) that will inform fundamental issues by developing models of mental disorder typology and identifying practical improvements in the classification systems.
Alcohol Use Disorders In Young Adults: Youthful Epidemic Or Diagnostic Bias?
Funder
National Health and Medical Research Council
Funding Amount
$198,874.00
Summary
Epidemiological studies show that 1 in 5 Australians aged 18-24 are diagnosed as having an alcohol use disorder. However, there is evidence to suggest that young adults may interpret the diagnostic criteria differently to older adults. The current study aims to validate the alcohol use disorder criteria in younger populations through the use of novel cognitive interviewing techniques.
Towards Global Control Of Scabies: Advances In Diagnosis, Treatment And Community Control
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The scabies mite causes severe itch and rash and leads to infections, kidney and heart disease. Scabies affects up to 50% of children in Indigenous communities. We now know most scabies can be prevented, so we urgently need to find the most effective strategies. My research will develop new tests to help doctors to accurately diagnose scabies. I will test new medicines to treat scabies and strategies to prevent scabies and its complications in children, families and entire populations.
Linkage And Association Studies Of Schizophrenia In An Isolated Population.
Funder
National Health and Medical Research Council
Funding Amount
$693,726.00
Summary
The cause of schizophrenia is unknown, but there is good evidence that genes play a role. Geneticists do not fully understand how the disease is inherited, but it is very complex, and several interacting genes as well as environmental factors are likely involved. To address this complexity, we have recruited large schizophrenia pedigrees from the Iban of Sarawak, a geographically and genetically isolated population. This sample will help clarify the genetics of this devastating illness.
Non-Alzheimer Dementia: Pathogenesis And Clinicopathological Correlations
Funder
National Health and Medical Research Council
Funding Amount
$437,036.00
Summary
Dementia affects as many as 20% of people in their eighties. Although much of this is caused by Alzheimer's disease (AD), other types of dementia are also important. In this study we will look at two types of non-Alzheimer dementia, frontotemporal dementia (FTD) and small vessel cerebrovascular disease (SVD). The clinical symptoms of SVD closely resemble AD. Conversely, FTD results in degeneration of those parts of the brain which are responsible for personality, behaviour and language. We will ....Dementia affects as many as 20% of people in their eighties. Although much of this is caused by Alzheimer's disease (AD), other types of dementia are also important. In this study we will look at two types of non-Alzheimer dementia, frontotemporal dementia (FTD) and small vessel cerebrovascular disease (SVD). The clinical symptoms of SVD closely resemble AD. Conversely, FTD results in degeneration of those parts of the brain which are responsible for personality, behaviour and language. We will look at the brains of patients who have died with these diseases and determine the types of neurons which are damaged and their distribution in the brain. We will also investigate whether an individual's genetic make-up influences the development of SVD. In addition, in collaboration with neuropathologists across Australia, we will develop and standardise criteria for the pathological diagnosis of these diseases. Overall, this study will better characterise the pathology of two commonly encountered non-AD dementias and provide valuable insights into their causes.Read moreRead less
Studying The Molecular Basis Of Schizophrenia In A Large, Globally Competitive Indian Sample
Funder
National Health and Medical Research Council
Funding Amount
$998,040.00
Summary
This study will attempt to identify genetic factors contributing to the development of schizophrenia, a severe mental illness which causes an immense burden on families. In India, there are 7-8 million sufferers, with approximately 30-40% untreated, especially in rural areas. We aim to recruit over 2000 people with and 3000 without schizophrenia, and analyse DNA to identify schizophrenia susceptibility genes. This may lead to better treatments and earlier diagnosis.
Mapping And Treating Early Clinical Stages Of Mental Disorders During Transition To Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The research proposed in this Fellowship is aimed at young people with emerging mental ill-health. The specific goals and targets are to formulate novel diagnoses that work; develop novel, personalised and safe psychosocial and biotherapies; and scale up well-evaluated 21st century models of mental health care.