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Discovery Early Career Researcher Award - Grant ID: DE160101565
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodol ....Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodologies in finite mixture modelling using skew component distributions to provide better models for handling data with non-normal features (such as skewness, heavy/light tails, and multimodality). Applications may include security intrusion detection, clinical diagnosis and prognosis, and flow and mass cytometry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101005
Funder
Australian Research Council
Funding Amount
$378,288.00
Summary
Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. ....Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. These minimally invasive devices will produce information-rich multidimensional fused image and sensor data, opening up new possibilities for biologists and medical researchers to study disease progression and treatment in living animals and humans, with great potential for scientific discovery.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100564
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into th ....Vascularized tumour models to elucidate the delivery of nanomedicine agents. This inter-disciplinary project aims to develop advances in in vitro models aimed at elucidating the delivery and transport of diagnostic and therapeutic nanomedicine agents in tumour tissues. The project aims to build on advanced tissue engineering principles and state-of-the-art micro-fabrication technologies to remove the limitation associated with animal studies and provide unprecedented mechanistic insights into the delivery, transport and binding of nanomedicines into tumour tissues.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101222
Funder
Australian Research Council
Funding Amount
$371,392.00
Summary
The development of novel magnetic resonance imaging methods to investigate brain structure and function. Magnetic resonance imaging (MRI) is a non-invasive method that has revolutionised neuroscience. The goal of this project is to develop state-of-the-art MRI analysis methods that reveal new information about brain structure and function. These novel neuroimaging tools will be instrumental in furthering our understanding of how the brain works.
Discovery Early Career Researcher Award - Grant ID: DE220100846
Funder
Australian Research Council
Funding Amount
$418,388.00
Summary
Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a ne ....Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a new strategy to brighten the upconversion nanomaterials. This project should push upconversion nanoscience to a new generation and provide significant benefits in ultra-sensitive biomolecular assays and in vivo bioimaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102352
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Three-dimensional structural imaging in optical microscopy and tomography. This project will develop fundamentally new strategies for looking inside live cells to determine their internal structures. Such capability will permit a better understanding of diseases, the link between diabetes and heart failure for example, opening the door for new diagnostic techniques and treatments.
Discovery Early Career Researcher Award - Grant ID: DE160101101
Funder
Australian Research Council
Funding Amount
$348,741.00
Summary
Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronic ....Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronics from its current status as a fundamental tool to real-world applications. Key approaches will be the use of surface chemistry to develop new methods of wiring single molecules and the integration of robust single-molecule junctions with semiconducting electrodes. The expected project outcomes pave the way for single-molecule electronic and analytical devices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101655
Funder
Australian Research Council
Funding Amount
$297,036.00
Summary
Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretatio ....Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretation. It will help to alleviate the inter-observer variability and time-consuming process of manual analysis. The project aims to advance fundamental biomedical imaging research in generalised visual structure extraction and classification, and enable large-scale translational research in systems pathology for personalised cancer care.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100413
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evid ....Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evidence of the interaction between parenting practices and the developmental aspects of these disorders This project will examine oxytocin genetics in toddlers with disruptive behaviour disorders and their parents, to ultimately identify the genetic, family, and developmental processes that shape persistent disorders.Read moreRead less