Micropapillary Adenocarcinoma: The Emergence Of A Discrete Lung Cancer Phenotype And Its Genomic And Transcriptomic Characterization.
Funder
National Health and Medical Research Council
Funding Amount
$117,565.00
Summary
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Loop-mediated Isothermal Amplification(LAMP): A Novel Tool For The Diagnosis Of Mixed Malaria Infections In Elimination Settings
Funder
National Health and Medical Research Council
Funding Amount
$101,877.00
Summary
The malaria elimination agenda will require the development of novel, field applicable diagnostic tools to detect asymptomatic carriers of P.falciparum and non-falciparum malaria infections. Loop-mediated isothermal amplification (LAMP) has been demonstrated to be a novel, sensitive, specific nucleic acid amplification technique. My project aims to optimise LAMP into a high-throughput field applicable molecular diagnostic tool capable of diagnosing malaria in elimination settings
The Development Of A Loop-mediated Isothermal Amplification (LAMP) Assay For The Detection Of Strongyloides Stercoralis In The Stool.
Funder
National Health and Medical Research Council
Funding Amount
$127,494.00
Summary
A new test will be developed for the detection of the worm, Strongyloides stercoralis in the stool. S. stercoralis infects millions of people worldwide and occurs in the north of Australia. It can occasionally cause a ‘hyperinfection’ with fatal consequences. The test is based on the DNA detection method, loop-mediated isothermal amplification (LAMP), which can be performed using simple equipment. The aim will be to make this test as easy possible to perform and to evaluate its effectiveness.
The Use Of Next Generation Sequencing To Diagnose Neurogenetic Disease
Funder
National Health and Medical Research Council
Funding Amount
$55,689.00
Summary
For two groups of neurogenetic disease, leukodystrophy and polymicrogyria, the underlying genetic cause is not known for at least 50% of cases. In these cases, patients and their families do not have access to accurate genetic counselling, prognostic information or targeted therapeutics. This study will use new genetic technologies to identify the specific genetic causes underlying these diseases. These results will improve patient care and our understanding of the disease mechanisms.
Prediction Of Response To Neoadjuvant Breast Cancer Therapy By Magnetic Resonance Imaging (MRI)
Funder
National Health and Medical Research Council
Funding Amount
$67,321.00
Summary
Neoadjuvant chemotherapy (NAC) has a well-established role in the management of breast cancer. Various roles have been proposed for magnetic resonance imaging (MRI) in the NAC setting, including its application in prediction of final pathologic response when undertaken early during a planned NAC course; the detection of residual disease after completion of NAC; and the measurement of residual tumour extent. The present study aims to determine the accuracy of MRI (relative to other imaging and cl ....Neoadjuvant chemotherapy (NAC) has a well-established role in the management of breast cancer. Various roles have been proposed for magnetic resonance imaging (MRI) in the NAC setting, including its application in prediction of final pathologic response when undertaken early during a planned NAC course; the detection of residual disease after completion of NAC; and the measurement of residual tumour extent. The present study aims to determine the accuracy of MRI (relative to other imaging and clinical tests) in these clinical scenarios.Read moreRead less
Pathophysiological Decision-making In Children With Obsessive-compulsive Disorder And Tic Disorders: Action-selection And Imaging Correlates
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Why is it that a person with obsessive-compulsive disorder (OCD) has trouble deciding whether or not to wash their hands? We scanned the brains of teenagers with OCD while they made decisions and found that they had difficulty using cues in their environment to direct choices. This may be an early vulnerability for the development of the disorder that could guide prevention. We plan to check if that difficulty is present in younger children with OCD and their family members.
Diagnostic And Therapeutic Implications Of Whole Genome Sequencing And Phenotyping In Hereditary Spastic Paraplegia
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Prospective cohort study investigating progression measures in patients with hereditary spastic paraplegia including clinical phenotype, severity rating scales, motor evoked potentials and diffusion tensor imaging. These measures will be correlated with genotype using whole genome sequencing and measures of economic impact from this condition.
SFRP4 As A Novel Diagnostic And Therapeutic Target For Gastric Cancer
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Gastric cancer is a common cancer with poor survival, but is and potentially curable when diagnosed at an early stage. However currently there are no non-invasive markers for the early detection of gastric cancer, and treatments for advanced cancer are limited. Secreted frizzled related protein 4 (SFRP4) is a protein that is thought to play a role in invasion of gastric cancer. This study will investigate the utility SFRP4 as a diagnostic test and possible therapeutic for gastric cancer.
Lung cancer is a leading cause of cancer death globally. Symptoms may not develop until disease is advanced, so it is often incurable at diagnosis. Scientific developments have greatly improved our ability to test for the changes in DNA structure and function responsible for this deadly disease and its progression. This study examines whole lung cancer genomes then uses these findings to develop safer methods for detection based on changes in DNA sequence.