Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
DEEP DRILLING OF THE HUMAN PLASMA PROTEOME. Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers ....DEEP DRILLING OF THE HUMAN PLASMA PROTEOME. Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers. This is possible because undiscovered low copy number biomarkers (faint stars) exist in human diagnostic fluids at levels far lower than current proteomic array detection limits.Read moreRead less
Cloud-data centres resource allocation under bursty conditions. Cloud-data centres resource allocation under bursty conditions. The project aims to design, implement, and integrate solutions to manage resources in cloud data centres (CDCs), especially when operating under bursty workload conditions. CDCs are expected to assure performance whilst optimising resource usage at a minimum cost, but efficiently providing resources with specific performance requirements can be difficult. This project i ....Cloud-data centres resource allocation under bursty conditions. Cloud-data centres resource allocation under bursty conditions. The project aims to design, implement, and integrate solutions to manage resources in cloud data centres (CDCs), especially when operating under bursty workload conditions. CDCs are expected to assure performance whilst optimising resource usage at a minimum cost, but efficiently providing resources with specific performance requirements can be difficult. This project intends to develop scalable solutions with industry approved software plug-ins. This is expected to affect both trustworthy information and communications technology (ICT) infrastructure (delivering more resilient CDCs) and economic sustainability (reducing CDC usage cost for both users and providers) of today’s computerised society.Read moreRead less
Contention-Aware Scheduling in Cloud Data Centres. This project aims to design, implement, and integrate solutions to improve resource use of private cloud data centres (CDCs). CDCs are expected to guarantee performance while optimising resource usage at a minimum cost. This incurs technical challenges that must be tackled to efficiently provision on-demand resources with specific performance requirements. The project intends to push the applicability of both current techniques and the ones to b ....Contention-Aware Scheduling in Cloud Data Centres. This project aims to design, implement, and integrate solutions to improve resource use of private cloud data centres (CDCs). CDCs are expected to guarantee performance while optimising resource usage at a minimum cost. This incurs technical challenges that must be tackled to efficiently provision on-demand resources with specific performance requirements. The project intends to push the applicability of both current techniques and the ones to be designed in this project to industry-scale CDCs, and identify metrics and variables to holistically control service-level agreements of hosted applications. Scalable solutions with industry approved software plug-ins are the major outcomes of this project. The outcomes of this project will have a substantial impact on both environmental (lowering energy consumption to lead to greener infrastructure) and economic sustainability (reducing cloud usage cost for both users and providers) of today’s much computerised society.Read moreRead less
Energy-Efficient Computing: Expanding the Role of Scheduling in Cloud Data Centres. Cloud data centres have become increasingly large-scale to meet ever increasing computing and storage capacity. The requirement of uninterrupted service availability has also contributed to such expansion. However, this relentless pursuit of high performance and high availability has led to serious resource over-provisioning and, in turn, low performance to energy consumption ratios. The impact of this poor resou ....Energy-Efficient Computing: Expanding the Role of Scheduling in Cloud Data Centres. Cloud data centres have become increasingly large-scale to meet ever increasing computing and storage capacity. The requirement of uninterrupted service availability has also contributed to such expansion. However, this relentless pursuit of high performance and high availability has led to serious resource over-provisioning and, in turn, low performance to energy consumption ratios. The impact of this poor resource management goes beyond the issue of cloud data centre efficiency, including excessive carbon footprint. This project aims to develop new energy-aware scheduling and resource allocation algorithms to provide energy-efficient solutions. These solutions exploit both workload and system diversity in cloud data centres.Read moreRead less
Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in preg ....Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in pregnant women, and to further develop such antibodies for therapy. Identification of mothers at risk of FMAIT and the development of a specific therapy are vital to the management and prevention of this serious condition.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult l ....New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult life. This project will also provide domain trained researchers with cutting edge international academic and industry expertise.Read moreRead less