Evolutionary algorithms for problems in functional genomics data analysis. Skin cancer has a high incidence in the Australian population. Schizophrenia is a psychiatric disorder that affects a significant proportion of the population worldwide. Both illnesses have genetic roots and can be triggered by environmental factors. We will uncover genetic relationship to disease and their responses to environmental conditions using computational methods and mathematical algorithms that can aid in the de ....Evolutionary algorithms for problems in functional genomics data analysis. Skin cancer has a high incidence in the Australian population. Schizophrenia is a psychiatric disorder that affects a significant proportion of the population worldwide. Both illnesses have genetic roots and can be triggered by environmental factors. We will uncover genetic relationship to disease and their responses to environmental conditions using computational methods and mathematical algorithms that can aid in the determination of function, especially in disease states. Understanding the complex genetic interactions that trigger these illnesses would give great benefits in preventive health care, skin cancer and schizophrenia genetic basis, and may lay the ground for building new methods for "personalized medicine".
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Application of novel exact combinatorial optimisation techniques and metaheuristic methods for problems in cancer research. Novel biotechnologies are offering an unprecedented opportunity to understand the genetic basis of cancer development and progression. However, they present us with a challenge; new computational methods and improved mathematical models and algorithms need to be introduced to complement these technologies in the determination of the function of our individual genetic makeup ....Application of novel exact combinatorial optimisation techniques and metaheuristic methods for problems in cancer research. Novel biotechnologies are offering an unprecedented opportunity to understand the genetic basis of cancer development and progression. However, they present us with a challenge; new computational methods and improved mathematical models and algorithms need to be introduced to complement these technologies in the determination of the function of our individual genetic makeup, especially in connection with disease states. The project will deal with research questions and datasets related to some of the highest incidence cancers in Australia. This project will contribute towards the development of new powerful algorithms for pattern recognition for future "personalized" molecular diagnostics methods.Read moreRead less
Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinicia ....Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinician to reduce fetal deaths and enhance the chances of good outcomes with resultant savings in social and financial costs to the community. The development of such equipment would spawn future research into intervention treatments and contribute to Australia's position as a world leader in computerised health monitoring systems.Read moreRead less
Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protei ....Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protein diagnostic array technology will enable accurate and rapid diagnosis of disease, generating savings on health costs and improving public health. Manufacture in Australia will bring further economic benefits.Read moreRead less
Compilation Techniques for Embedded Systems. Highly optimising compiler tools are becoming an important part of the software development process for embedded systems. This project will provide Australia with core technology in the area of tools for embedded systems. It will allow safer embedded systems in mission-critical applications. In addition, the Australian Industry will benefit from a substantially growing embedded systems market where tools are a pre-requisite for a cost-aware and safe s ....Compilation Techniques for Embedded Systems. Highly optimising compiler tools are becoming an important part of the software development process for embedded systems. This project will provide Australia with core technology in the area of tools for embedded systems. It will allow safer embedded systems in mission-critical applications. In addition, the Australian Industry will benefit from a substantially growing embedded systems market where tools are a pre-requisite for a cost-aware and safe software development. The industry interested in embedded system tools are: Telecom/Datacom, Consumer Electronics, Industrial Automation, Retail Automation, Office Automation, Military/Aerospace, Automotive, Information Automation, Medical Devices.Read moreRead less
Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient al ....Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient algorithmic approaches for difficult problems enable advances in all areas of computer applications such as medical diagnosis and health prediction, national security, communications efficiency, industrial productivity and all fields of science and engineering.Read moreRead less
Algebraic Models of Stream Ciphers. The project investigates communication security in the mobile environment where both confidentiality and authenticity are of a prime concern. Stream ciphers are a natural choice in mobile environments as they provide an efficient cryptographic protection using a limited computing resources. We treat stream ciphers as algebraic objects whose properties fully determine their cryptographic strength. We first analyse existing stream ciphers showing their algebraic ....Algebraic Models of Stream Ciphers. The project investigates communication security in the mobile environment where both confidentiality and authenticity are of a prime concern. Stream ciphers are a natural choice in mobile environments as they provide an efficient cryptographic protection using a limited computing resources. We treat stream ciphers as algebraic objects whose properties fully determine their cryptographic strength. We first analyse existing stream ciphers showing their algebraic properties and later we derive a design methodology for provably secure stream ciphers. The project leads to new secure and efficient designs for stream ciphers that are the preferred cryptographic tools used in Australian industry.Read moreRead less
Algebraic Analysis of Cryptosystems. This project studies an (new) algebraic approach to cryptanalysis of modern block ciphers. The approach works for all cryptosystems that use either small S-boxes, or their algebraic structure can be described by a system of overdefined quadratic equations. The cryptosystems that are potentially breakable using this approach are Rijndael and Serpent - the two top finalists of the Advanced Encryption Standard contest. The project also explores how this approach ....Algebraic Analysis of Cryptosystems. This project studies an (new) algebraic approach to cryptanalysis of modern block ciphers. The approach works for all cryptosystems that use either small S-boxes, or their algebraic structure can be described by a system of overdefined quadratic equations. The cryptosystems that are potentially breakable using this approach are Rijndael and Serpent - the two top finalists of the Advanced Encryption Standard contest. The project also explores how this approach can be applied to design new and more powerful factoring algorithms. The project has an explosive potential to redefine the theory and practice of modern cryptography.Read moreRead less
Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunitie ....Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunities for new theories in the design of new heuristics and in turbocharging existing heuristics for computationally hard problems.Read moreRead less
Algorithmics for Extremely Mobile Wireless Networks. Existing wireless network protocols need stringent conditions to be effective. These conditions are rarely met for concrete applications such as Defence, Disaster-Relief, Search-and-Rescue. All these cannot rely on existing infrastructure, and often require high mobility. This is crucial in the case of Australia which cannot rely on complete network coverage of its lands and seas. This project will develop new wireless protocols for applicati ....Algorithmics for Extremely Mobile Wireless Networks. Existing wireless network protocols need stringent conditions to be effective. These conditions are rarely met for concrete applications such as Defence, Disaster-Relief, Search-and-Rescue. All these cannot rely on existing infrastructure, and often require high mobility. This is crucial in the case of Australia which cannot rely on complete network coverage of its lands and seas. This project will develop new wireless protocols for applications requiring extreme mobility. It will increase Australia's control of this, now ubiquitous, technology thus rendering Australia a key player in this field.Read moreRead less