The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be model ....The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be modelled using all the available genetic information. Computer predictions will be experimentally tested in the PANBIO laboratory by using the probes to detect viral nucleic acids. The influence of virus genome complexity will be investigatedRead moreRead less
New Methods for Directed Molecular Evolution of Novel Protein Functions. Novel ribosome-based techniques can be used to carry out test-tube evolution of proteins with new structures and functions. The methods rely on (a) physical association of individual nucleic acid molecules with the particular protein molecules they encode, (b) selection of proteins with new functions, and (c) recovery of the attached genetic code. This project will address several issues that currently limit use of these fr ....New Methods for Directed Molecular Evolution of Novel Protein Functions. Novel ribosome-based techniques can be used to carry out test-tube evolution of proteins with new structures and functions. The methods rely on (a) physical association of individual nucleic acid molecules with the particular protein molecules they encode, (b) selection of proteins with new functions, and (c) recovery of the attached genetic code. This project will address several issues that currently limit use of these frontier technologies for evolution of new protein products that have a wide range of practical applications.Read moreRead less
Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
More bang for your carbon buck: carbon, biodiversity and water balance consequences of whole-catchment carbon farming. Farming carbon via tree plantings on pasture land is becoming increasingly common to address the effects of climate change. This activity is likely to produce dramatic changes in Australia's rural landscapes, but we have little knowledge of likely effects on crucial ecosystem services and attributes such as stream water yields and biodiversity. This project will investigate the ....More bang for your carbon buck: carbon, biodiversity and water balance consequences of whole-catchment carbon farming. Farming carbon via tree plantings on pasture land is becoming increasingly common to address the effects of climate change. This activity is likely to produce dramatic changes in Australia's rural landscapes, but we have little knowledge of likely effects on crucial ecosystem services and attributes such as stream water yields and biodiversity. This project will investigate the relationship between tree cover, carbon uptake, water yield and biodiversity. The outcomes will allow government agencies, landowners and carbon farming groups to better evaluate the effects of different landscape planning options and contribute to effective long-term planning for multiple goals.Read moreRead less
Our rural wealth: using functional responses of native fauna to predict conservation values of agricultural landscapes. The aim of this project is to develop and test a new approach for assessing the conservation value of agricultural landscapes in Australia. It is based on identifying the functional responses of the fauna to the extent and pattern of native vegetation and types and intensity of agricultural land-uses in whole landscapes. Different response types will be interpreted in relatio ....Our rural wealth: using functional responses of native fauna to predict conservation values of agricultural landscapes. The aim of this project is to develop and test a new approach for assessing the conservation value of agricultural landscapes in Australia. It is based on identifying the functional responses of the fauna to the extent and pattern of native vegetation and types and intensity of agricultural land-uses in whole landscapes. Different response types will be interpreted in relation to ecological characteristics of species. We will use this knowledge to predict the status of birds and mammals in novel landscapes in three bioregions, and test the predictions by field studies. This new landscape-level approach will help land managers assess present agricultural environments as well as evaluate scenarios for future changes in land-use.Read moreRead less
Models for biodiversity futures for massively altered agricultural landscapes. Problems with soil and water and declines in native biodiversity have been linked to clearance of native vegetation. We consider future landscapes with substantially more native vegetation than at present to deal with these natural resource problems. Plantings will be slow to mature so optimal planning for landscape revegetation must consider how long it will take for the new vegetation to provide suitable habitat, bo ....Models for biodiversity futures for massively altered agricultural landscapes. Problems with soil and water and declines in native biodiversity have been linked to clearance of native vegetation. We consider future landscapes with substantially more native vegetation than at present to deal with these natural resource problems. Plantings will be slow to mature so optimal planning for landscape revegetation must consider how long it will take for the new vegetation to provide suitable habitat, both at patch and landscape scales. We will develop an optimization framework incorporating models of vegetation maturation and biotic responses to aid designs for placement and scheduling of replantings to give the best outcomes for biodiversity management given constraints on amounts of retired area and costs of implementation.Read moreRead less
Modelling policy interventions to protect Australia's food security in the face of environmental sustainability challenges . This project will use an innovative scenario modelling approach to quantify the potential impacts of population growth and emerging climate and environmental challenges on Australia’s future food security. In collaboration with an advisory committee it will specify and prioritise policy solutions in terms of their social and economic credentials.
Integrated Photonics for Secure Communication and Related Applications in Financial Transaction Data Analysis. The project includes excellent basic science, semiconductor device fabrication and applied mathematics with explicitly identified consequences for innovation. There is strong potential for national economic benefits through the manufacture of new integrated photonic devices, the application of these devices in secure communication systems, the research of advanced non-linear analysis pr ....Integrated Photonics for Secure Communication and Related Applications in Financial Transaction Data Analysis. The project includes excellent basic science, semiconductor device fabrication and applied mathematics with explicitly identified consequences for innovation. There is strong potential for national economic benefits through the manufacture of new integrated photonic devices, the application of these devices in secure communication systems, the research of advanced non-linear analysis protocols, and the implementation of these in financial transaction analysis. Professional development and research education of postgraduate students and early career researchers will be carried out in a multi-disciplinary research environment with ongoing uptake of the research in industry and commercial sectors.Read moreRead less
Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mi ....Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mitigate their ecological impacts and provide essential ecosystem services such as pollution abatement. This project will investigate the efficacy of these designs with both classical measures of diversity and structure and novel measures of ecosystem function. The project aims to provide essential information to inform the design of future marine urban developments.Read moreRead less
Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.