Defining The Role Of MiR-146a In Human Hendra Virus Infections
Funder
National Health and Medical Research Council
Funding Amount
$348,998.00
Summary
This project aims to improve the medical management of people infected with Hendra virus by defining potential therapeutic windows for treatment with antiviral strategies. The project involves the study of microRNAs, a class of small ribonucleic acid molecules that regulate biological processes in eukaryotes. We will determine the role of microRNAs in the Hendra virus infection process in humans, and their application as diagnostic markers of Hendra virus infection.
This Fellowship will develop novel diagnostic techniques in those patients who are at risk of developing Dementia and Parkinson’s Disease. Participants will also be encouraged to enrol in a brain donation program allowing detailed information for future correlations between symptoms and brain changes. This work will lead to the creation of a diagnostic matrix (At Risk Index) that will provide clinicians and researchers with tools to inform better diagnosis, prognosis and therapy.
In Vivo Assessment Of The Role Of Aggregated Tau In Preclinical And Prodromal Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$612,269.00
Summary
Subtle changes in the brain precede an Alzheimer’s disease (AD) diagnosis by 20-30 years. These changes provide an incredible opportunity to diagnose and treat AD; however, our understanding of them, remains limited. We aim to use new imaging technologies to investigate these subtle changes in the preclinical AD brain. This will give us a greater understanding of how these early changes effect AD progression and whether we can use this information to improve the diagnosis and treatment of AD.