Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775763
Funder
Australian Research Council
Funding Amount
$189,000.00
Summary
High throughput orthogonal mass spectrometer for biotechnology research in WA. The new 'orthogonal' mass spectrometer will be housed at the WA State Agricultural Biotechnology Centre at Murdoch University (SABC). The SABC is a multi-user university centre that provides equal access for researchers from all universities, state government and industry to major facilities. The equipment will provide a competitive advantage to researchers undertaking fundamental and applied projects that underpin ....High throughput orthogonal mass spectrometer for biotechnology research in WA. The new 'orthogonal' mass spectrometer will be housed at the WA State Agricultural Biotechnology Centre at Murdoch University (SABC). The SABC is a multi-user university centre that provides equal access for researchers from all universities, state government and industry to major facilities. The equipment will provide a competitive advantage to researchers undertaking fundamental and applied projects that underpin new developments in plant and animal agriculture. Outcomes include: development of new molecular markers to speed crop improvement and quality, animal genetic improvement and health, and support for new biotechnology companies. This will benefit the community through more productive, competitive and sustainable agriculture.Read moreRead less
Functional Genomics to Predict and Enhance Response to Interferon. The increasing number and huge cost impost of new therapies to health providers, both worldwide and nationally, has not yet resulted in a concomitant increase in strategies to optimise their use. Many of the new therapies are proteins (recombinant human proteins or humanised monoclonal antibodies). The improved use of one of Australia's most expensive commonly used protein drugs, pegylated interferon ribavirin (Peg-IFN-R), could ....Functional Genomics to Predict and Enhance Response to Interferon. The increasing number and huge cost impost of new therapies to health providers, both worldwide and nationally, has not yet resulted in a concomitant increase in strategies to optimise their use. Many of the new therapies are proteins (recombinant human proteins or humanised monoclonal antibodies). The improved use of one of Australia's most expensive commonly used protein drugs, pegylated interferon ribavirin (Peg-IFN-R), could potentially produce savings to the Pharmaceutical Benefits Scheme (PBS), and improve delivery of healthcare to thousands of Australians.Read moreRead less
Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discov ....Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discovering these rules will provide novel insights in pathology with a genetic component and provide a further boost to biotechnological approaches to obtain expression of specific sets of genes in model systems. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668507
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, ....Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, pioneered by The University of Queensland (UQ) and Southern Cross University (SCU) using ARC funding in 1996, is now the technology of choice for much of this research. This project will provide high-throughput equipment for real time PCR, and will develop complementary high-throughput "nanoparticle" DNA genotyping technologies, with applications to medicine and agriculture.
Read moreRead less
New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to p ....New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to provide basic understanding of processes which can be developed into cost effective analyses for practical use by industry to ensure quality assurance.Read moreRead less
Application of genome-wide transcriptional analysis to identifying genetic markers for industrial fermentation processes. This project aims to identify yeast genes involved in the response of commercial strains to stress, to determine their role in fermentation and the genetic pathways through which they operate. The ultimate goals are to determine the impact on fermentation activity of stress, and to develop predictive methods for assessing such conditions. This has significance since stress ....Application of genome-wide transcriptional analysis to identifying genetic markers for industrial fermentation processes. This project aims to identify yeast genes involved in the response of commercial strains to stress, to determine their role in fermentation and the genetic pathways through which they operate. The ultimate goals are to determine the impact on fermentation activity of stress, and to develop predictive methods for assessing such conditions. This has significance since stress during fermentation represents a significant commercial loss. The outcomes of this work will be a better understanding of how yeast responds to stress, and the identification of genes that can be used by the commercial partner to monitor and ensure fermentation efficiency.Read moreRead less