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E-PREDICE Early Prevention Of Diabetes Complications In Europe
Funder
National Health and Medical Research Council
Funding Amount
$917,400.00
Summary
The e-PREDICE study will randomise 3000 people aged 45-74 with mild hyperglycaemia or early diabetes to treatment with intensive lifestyle modification alone, or plus metformin, or sitagliptin, or liraglutide, aiming to reduce diabetes eye, kidney and nerve damage. The Australian arm will be co-ordinated by the University of Sydney and other sites include Baker IDI Heart and Diabetes Institute, Royal Melbourne Hospital, St Vincent’s Hospital Melbourne and Royal Brisbane and Womens Hospital
Impact Of Exercise Intervention On The Phenome (Metabolism And Predictive Complications) In Well Characterised Prediabetes And New Onset Type 2 Diabetes Cohorts In China And Australia (TheDiabeEx.JointStudy).
Funder
National Health and Medical Research Council
Funding Amount
$567,323.00
Summary
This proposal will study people with prediabetes or a new diagnosis of type 2 diabetes, compared with a group with normal blood glucose, in China and in Australia. It will examine, in well defined cohorts: 1. the extent of traditional and more novel organ complications and metabolic markers early in the disease course; 2. in people with abnormal blood glucose, the potential benefits of an exercise regimen to their metabolic health, biomarkers and complications.
N-glycan Profiling As A Risk Stratification Biomarker For Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$549,644.00
Summary
This study sets out to establish an N-glycan biomarker profile of suboptimal health in a well-established cohort of adult Australians, the Busselton Healthy Ageing Study (BHAS) and Chinese (SHS cohort) . This biomarker profile will contribute to the future development of N-glycan traits as a tool for (i) risk prediction of chronic disease onset, in particular those chronic conditions that constitute type II diabetes mellitus, and (ii) the prediction of a patient’s response to treatment.
A Multi-ethnic Cohort And Intervention Trial To Identify Early Biomarkers For Type 2 Diabetes And Customise Individualized Environments For Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$597,376.00
Summary
Diabetes is often called a lifestyle disease, however, large clinical studies have shown that diabetes cannot always be prevented through lifestyle modification. This collaborative study between Shanghai Institutes of Biological Science and Sydney University will identify biomarkers that predict the development of type 2 diabetes. Using this knowledge, the best interventions (including diet, exercise and medications) to improve an individual’s risk profile for type 2 diabetes will be identified.
A Lifestyle Intervention Program For The Prevention Of Type 2 Diabetes Mellitus Among South Asian Women With Gestational Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$1,256,499.00
Summary
Gestational diabetes mellitus (GDM) is common in South Asian women, and many develop lifelong type 2 diabetes (T2DM) soon after delivery. Lifestyle change helps prevent T2DM, but we do not know how to introduce a sustainable service that will change lifestyles of young, busy and often poor women. We will test a unique intervention embedded within local health systems in 1414 women with GDM from 24 hospitals in South Asia, hoping to show that this intervention will prevent T2DM.
Improving The Management Of Diabetes In Pregnancy In Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,117,449.00
Summary
This study aims to optimise the management of diabetes in pregnancy (both gestational diabetes and pre-existing type 2 diabetes) and post-partum follow-up of these high risk women in order to reduce the risk of future chronic disease among women and their children. The proposal involves scale-up of successful initiatives that we have developed as part of the NT DIP Partnership, scale-up within the Northern Territory (NT) and to Far North Queensland (FNQ).
Identifying The Epigenomic Fingerprint Of Coronary Heart Disease In Chinese Adults With Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$596,663.00
Summary
Once people get diabetes, even good glucose control may be insufficient to prevent its complications. Diabetes results in molecular imprinting contributing to an increased risk of heart disease. We believe it is possible to identify this imprinted risk by a sophisticated analysis of a standard blood sample. Validating this hypothesis will lead to new biomarkers to identify individuals at increased risk of heart attacks as well as new strategies for the prevention and treatment of heart disease.
Dementia In Type 2 Diabetes – Studying Causal Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$514,786.00
Summary
Type 2 diabetes mellitus (T2D) is an important risk factor for dementia, and knowledge regarding the biological pathways linking the two disorders can provide great insight into the causes of dementia overall. I plan to study the links between T2D and dementia using analytical modelling to tease out causal pathways. My overall vision is to establish a sound knowledge base upon which effective interventions can be devised to prevent or delay dementia, using T2D-related dementia as a model.
Improving The Health Of Older Australians At Risk Of Dementia - The Role Of Physical Function And Exercise
Funder
National Health and Medical Research Council
Funding Amount
$533,120.00
Summary
This fellowship will support novel research to examine whether exercise can improve the cognitive and physical health of individuals at risk of dementia such as those with Type 2 Diabetes or cognitive impairment. Outcomes are likely to delay the onset of dementia and enable older Australians at risk of dementia to maintain independence and improved quality of life.
Regulation Of Cardiometabolic Disease By A Novel ATP Binding Cholesterol Transporter, ABCA8: A New Therapeutic Target?
Funder
National Health and Medical Research Council
Funding Amount
$316,585.00
Summary
Approximately 1.7 million Australians and 12% of the population in Singapore has type 2 diabetes (T2D). We have identified a cholesterol transporter, ABCA8, the absence of which produces symptoms similar to those seen in humans with T2D. The aim of this project is to understand the molecular basis of the diabetes symptoms in mice that do not have ABCA8 with a view to identifying this transporter as a drug target to reduce T2D and its complications, including heart attacks.