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The Relationship Between Non-Alcoholic Fatty Liver Disease And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Non alcoholic Fatty Liver Disease (NAFLD) threatens to become a major public health problem. Its increasing prevalence is associated with parallel increases in obesity and diabetes. This study aims to understand the mechanisms involved in progression to liver failure and liver cancer in the setting of diabetes and the impact of NAFLD on blood sugar levels and diabetes complications (esp. cardiovascular). Using a recently developed animal model of type 2 diabetes and fatty liver, it will better d ....Non alcoholic Fatty Liver Disease (NAFLD) threatens to become a major public health problem. Its increasing prevalence is associated with parallel increases in obesity and diabetes. This study aims to understand the mechanisms involved in progression to liver failure and liver cancer in the setting of diabetes and the impact of NAFLD on blood sugar levels and diabetes complications (esp. cardiovascular). Using a recently developed animal model of type 2 diabetes and fatty liver, it will better define a novel therapeutic agent.Read moreRead less
There is a link between maternal lipids and newborn weight as well as other adverse pregnancy outcomes. Maternal lipids _ serum level, dietary intake and change in maternal lipids during pregnancy may be important in determining not only immediate pregnancy and newborn outcomes but also longer term problems for mother and child. As yet, we do not know whether altering maternal lipids will change outcomes or how to influence lipid levels in practice or how best to approach this.
Type 1 Diabetes And The Metabolic Syndrome: Defining This Modern-day Phenotype, And Exploring The Effects Of Exercise On Glycaemic Control And Both Traditional And Novel Diabetes Complications
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
This research aims to define trends in the prevalence of, and complications associated with, metabolic syndrome in adults with type 1 diabetes, using the Australian National Diabetes Information Audit and Benchmarking Initiative (ANDIAB). Subsequently, a randomised controlled trial will examine the effect of exercise on glycaemic control and diabetes complications risk profiles in this group. These studies will thus address disease profiles and a potential beneficial clinical intervention.
Diabetes And Cardiovascular Risk Among Indigenous Women After Pregnancy Complicated By Hyperglycaemia.
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Indigenous Australian women are at high risk of having GDM which increases the risk of developing both GDM in future pregnancies and T2DM. We want to clarify these risks and whether there are differences between Indigenous and non-Indigenous women. Ideally, we can intervene to prevent this cycle of disease as diabetes in pregnancy has long term poor health outcomes for both mothers and their offspring.
Accelerated Telomere Length Attrition Rate In Diabetes And Its Cellular Mechanism
Funder
National Health and Medical Research Council
Funding Amount
$38,381.00
Summary
I am a PhD in Medicine-University of Sydney. My research focus is about telomere dynamic, its mechanism and correlation between telomere length and diabetes attributes. I will compare telomere length between different diabetes groups & examine telomere regulation in cell culture/animal model to compliment my clinical data. The hypothesis: accelerated telomere shortening may co-segregate with diabetes complications and by preserving telomere we could potentially prevent adverse effect of diabetes
Targeted Nanoparticle Delivery Of Agents To The Placenta To Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We have developed a new technique to deliver treatments only to the placenta, sparing the mother and baby from side effects. We will test whether this technique can treat the source of preeclampsia, the placenta, in mouse models and human tissue samples in the laboratory. This work may offer possibilities of new treatments to other pregnancy complications.
HtrA4-induced Endothelial Dysfunction In Early-onset Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
Preeclampsia (PE), a life-threatening disorder of pregnancy, is characterized by a sudden increase in blood pressure in association with wide-spread endothelial dysfunction. Placenta-derived factors are believed to cause PE development. Our recent studies have identified that HtrA4, a placenta-specific serine protease may contribute to endothelial dysfunction. This study will investigate the mechanisms of HtrA4-induced endothelial dysfunction.
Health Consequences For Mother And Baby Of Substantial Pre-conception Weight Loss In Obese Women
Funder
National Health and Medical Research Council
Funding Amount
$93,418.00
Summary
Obesity (BMI >30kg/m2) is now very common in women of child-bearing age.There is strong evidence that maternal obesity increases the rate of pregnancy complications, and affects the growth and well-being of the fetus in-utero. This project aims to determine how substantial pre-conception weight loss, achieved using a Very Low Energy Diet (VLED), impacts maternal and neonatal health outcomes.
Analysis Of Effect Of Different Treatment Targets On Maternal And Child Health Outcomes In Gestational Diabetes Mellitus (GDM), Review Of Specific Treatments And Development Of Clinical And Biochemical Predictors.
Funder
National Health and Medical Research Council
Funding Amount
$122,686.00
Summary
This research aims to analyse newly proposed treatment targets for Gestational Diabetes Mellitus (GDM) and the effect this will have on maternal and child health outcomes, via comparison of data from two large Australian health services using the traditional and newly proposed critiera. The research will also investigate current effective interventions for GDM, including the impact of early antenatal lifestyle interventions, and formulation of a clinical and biochemical risk prediction model.