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Enterovirus, Vitamin D Status And Inflammation At The Clinical Onset Of Type 1 Diabetes In Childhood
Funder
National Health and Medical Research Council
Funding Amount
$410,542.00
Summary
Type 1 diabetes is a serious disease that is increasing in incidence among Australian children. This project will build on an exsisting study to provide new information on the role of enteroviral infection, vitamin D status and the associated inflammatory changes in blood at the onset of disease.
FIELD LIFE: Lifestyle Interactions In Fenofibrate And The Epigenome
Funder
National Health and Medical Research Council
Funding Amount
$1,071,754.00
Summary
Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Obesity, Pre-diabetes And Future Risk Of Diabetes: Maximising The Evidence, Minimising The Cost
Funder
National Health and Medical Research Council
Funding Amount
$470,136.00
Summary
The overarching aim of this proposal is to reliably determine how best to identify people at high risk of developing future diabetes. We will do this by using information on biological and behavioural risk factors that was collected on nearly 200,000 people many years ago and who were subsequently followed up to see who developed diabetes. This information will be used to create a risk prediction tool for spotting individuals most at risk of developing diabetes at some point in the future.
The Role Of Bisphenol A In The Development Of Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$397,549.00
Summary
There is accumulating evidence to suggest that the environment we live in may be important in the development of chronic disease. This project examines a key environmental toxin Bisphenol A (BPA) and explores the role it has in the development of diabetes, obesity and cardiovascular disease (CVD). In this project, we will explore whether there is an independent relationship between BPA and the development of diabetes, CVD and obesity in humans in a prospective setting.