Type 2 Diabetes Mellitus And Cognitive Decline - A Longitudinal Study Of Effects And Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$1,317,589.00
Summary
Diabetes mellitus and dementia are major public health problems. Diabetes may increase the risk of dementia. This longitudinal study aims to uncover the mechanism by which diabetes may increase dementia risk. This may lead to finding new ways to prevent or treat diabetes-related dementia and thus reduce the public health burden of dementia.
Novel Retinal Architectural Vascular Signs And Risk Of Cardiovascular Disease: The AusDiab Study
Funder
National Health and Medical Research Council
Funding Amount
$754,254.00
Summary
Cardiovascular disease (CVD) and diabetes are major health problems. Identifying 'people at risk' is critical to design preventative strategies. We have developed new computer software to measure detailed characteristics of retinal vessels. By appling this system to predict CVD or diabetes in the AusDiab Study we aim to find 'the best combination of risk factors' to predict CVD and diabetes. This will open up the possibility of new risk assessment using a simple 'eye scan.'
Harnessing Multiple Large Datasets To Answer Critical Questions On Diabetes Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
This proposal will examine novel causes and consequences of diabetes using three approaches. Firstly, it will examine diabetes trends. Secondly, it will use the Australian Diabetes Registry linked to several key government database to explore important research questions, related to diabetes treatment, dementia and endstage kidney disease, which previously were not able to be answered. Thirdly, it will examine the role of environmental pollutants in the development of chronic disease.
A Study Of Mechanisms Of Cognitive Decline In Type 2 Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$510,222.00
Summary
Diabetes mellitus and dementia are major public health problems. Diabetes may increase the risk of dementia. This study aims to uncover the mechanism by which diabetes may increase dementia risk. This may lead to finding new ways to prevent or treat diabetes-related dementia and thus reduce the public health burden of dementia.
FIELD LIFE: Lifestyle Interactions In Fenofibrate And The Epigenome
Funder
National Health and Medical Research Council
Funding Amount
$1,071,754.00
Summary
Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.
The Incidence And Predictors Of Foot Disease Hospitalisation
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Foot disease seems to be a much larger cause of hospitalisation than first thought. This research program aims to study for the first ever time the annual incidence of foot disease hospitalisation and develop models to predict which patients with foot disease are likely to be hospitalised or die. We believe this research will help clinicians, researchers and governments from around the world to measure, predict and prevent foot disease hospitalisation in their nations for the first time.
Diabetes And Obesity: From Benchtop To Public Health
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
Obesity. Novel factors, not related to food intake or physical activity, will be explored as possible causes of obesity. The obesity paradox, in which overweight is associated with reduced mortality, will be examined. Diabetes treatment. Methods will be developed to predict which is the right drug for each individual patient. A study will test the use of nurse-led clinics. A novel insulin delivery mechanism will be developed. Novel causes and consequences of diabetes will be explored.