Discovery Early Career Researcher Award - Grant ID: DE180100306
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Does spurious maternal-fetal signalling support the evolution of a placenta. This project aims to test a model that explains how the placenta has evolved as a new organ more than 100 times in fishes, reptiles, and mammals including our own ancestors. The project will assess whether regulatory components of the placenta evolve as a result of spurious maternal-fetal signalling following egg retention and eggshell loss in viviparous reptiles. Expected outcomes of this project include a new understa ....Does spurious maternal-fetal signalling support the evolution of a placenta. This project aims to test a model that explains how the placenta has evolved as a new organ more than 100 times in fishes, reptiles, and mammals including our own ancestors. The project will assess whether regulatory components of the placenta evolve as a result of spurious maternal-fetal signalling following egg retention and eggshell loss in viviparous reptiles. Expected outcomes of this project include a new understanding of how complex organs originate and evolve in animals. This will benefit society through a broader depth of understanding of our own evolutionary history and provides a framework for future studies to investigate the origin and evolution of organs more broadly in animals.Read moreRead less
Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less
Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution. The heart has dramatically increased in morphological complexity during vertebrate evolution but the molecular basis driving these major changes remains unknown. Using comparative genomics approaches, this project will explore changes in the regulation of genes involved in heart formation that lead to changes in cardiac structure. It will elucidate for the first time t ....Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution. The heart has dramatically increased in morphological complexity during vertebrate evolution but the molecular basis driving these major changes remains unknown. Using comparative genomics approaches, this project will explore changes in the regulation of genes involved in heart formation that lead to changes in cardiac structure. It will elucidate for the first time the cardiac regulatory repertoire in zebrafish and will compare it with that of fly and mouse using cutting-edge bioinformatics pipelines. This work will unravel cardiac-specific regulatory modifications that give rise to evolutionary changes. On a broader scale, it will shed new light on the role of regulatory innovations over gene innovations in the emergence of new traits.Read moreRead less
Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Discovering sources of individual differences in first language acquisition. This project aims to investigate the processes of language acquisition to support the development of evidence-based strategies for improving children's early language. Some children learn language earlier and more easily than others. Understanding why this is the case is important because successful acquisition is strongly associated with positive life outcomes such as academic achievement and psychological wellbeing. T ....Discovering sources of individual differences in first language acquisition. This project aims to investigate the processes of language acquisition to support the development of evidence-based strategies for improving children's early language. Some children learn language earlier and more easily than others. Understanding why this is the case is important because successful acquisition is strongly associated with positive life outcomes such as academic achievement and psychological wellbeing. This project focuses on typically developing children, investigating how their ability to detect frequently occurring patterns in the environment significantly contributes to their acquisition of grammar in early childhood. The project plans to use an innovative triangulation of experimental methods from developmental psychology, longitudinal analysis and cognitive modelling to drive the development of new models of language acquisition and transform our understanding of both typical and atypical acquisition.Read moreRead less
Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do develo ....Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do developmental delays in acquiring a theory of mind explain some of the peer problems that children with autism or deafness face? The proposed longitudinal project aims to be the first to supply a comprehensive and causally convincing answer to these core questions.Read moreRead less
The Helmsman Project: Giving at-risk adolescents skills to navigate life’s journey and make a difference. This project aims to investigate how to keep able but disadvantaged youth engaged in school and give them the psychological tools they need to succeed. To meet this challenge, this project aims to propose a randomised control and extended baseline control test of a combined personal coaching and outdoor education (sailing experience) program designed to foster positive psychological outcomes ....The Helmsman Project: Giving at-risk adolescents skills to navigate life’s journey and make a difference. This project aims to investigate how to keep able but disadvantaged youth engaged in school and give them the psychological tools they need to succeed. To meet this challenge, this project aims to propose a randomised control and extended baseline control test of a combined personal coaching and outdoor education (sailing experience) program designed to foster positive psychological outcomes by developing goal strategies, hope, resilience, and self-regulation. The study aims to be extensive and novel, capturing the experiences of not just the participants but their peers, parents, teachers, and alumni mentors of the program. Both traditional survey and experience sampling data will be collected.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Reducing Cyberbullying: Turning Bystanders into Constructive Defenders. This project aims to develop a theoretically driven internet-based training program to reduce cyberbullying among adolescents. It expects to discover how to turn passive bystanders (onlookers) into active constructive defenders who help to stop cyberbullying and assist those being cyberbullied. Expected outcomes include developing the first theoretical model of bystanders in the cyberbullying context and practical evidenced ....Reducing Cyberbullying: Turning Bystanders into Constructive Defenders. This project aims to develop a theoretically driven internet-based training program to reduce cyberbullying among adolescents. It expects to discover how to turn passive bystanders (onlookers) into active constructive defenders who help to stop cyberbullying and assist those being cyberbullied. Expected outcomes include developing the first theoretical model of bystanders in the cyberbullying context and practical evidenced-based methods to increase constructive bystanding. The provision of an accessible training program for use in schools will produce significant benefits for the well-being of Australian youth by reducing cyberbullying and increasing the civility of Australian youth.
Read moreRead less